Effects of Forssman antibody on renal function of the guinea pig

When guinea pigs were injected with rabbit anti-sheep red blood cell antiserum (Forssman antibody) by the intra arterial (i.a.) route (abdominal aorta at the level of the renal arteries), they developed renal disfunction. A diminished glomerular filtration rate associated with a 27% increase in the fractional excretion of K+ was observed. No alterations were noted in the fractional excretion of water and NA+.