Inhibition of superoxide, anion production in guinea pig polymorphonuclear leukocytes by a seleno-organic compound, Ebselen
Production of superoxide anion (O2-) induced by tetradecanoyl phorbol acetate (TPA) in intact guinea pig polymorphonuclear leukocytes (PMNL) was markedly inhibited by a seleno-organic compound, 2-phenyl-1,2-benzisoselenazol-3(2H)-one (Ebselen), with glutathione peroxidase-like activity. The compound...
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| Veröffentlicht in: | Journal of pharmacobio-dynamics 1987, Vol.10 (10), p.595-597 |
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| container_end_page | 597 |
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| container_issue | 10 |
| container_start_page | 595 |
| container_title | Journal of pharmacobio-dynamics |
| container_volume | 10 |
| creator | ICHIKAWA, S OMURA, K KATAYAMA, T OKAMURA, N OHTSUKA, T ISHIBASHI, S MASAYASU, H |
| description | Production of superoxide anion (O2-) induced by tetradecanoyl phorbol acetate (TPA) in intact guinea pig polymorphonuclear leukocytes (PMNL) was markedly inhibited by a seleno-organic compound, 2-phenyl-1,2-benzisoselenazol-3(2H)-one (Ebselen), with glutathione peroxidase-like activity. The compound almost completely inhibited O2- production by a particulate fraction prepared from TPA-treated PMNL at a concentration as low as 250 nM. |
| doi_str_mv | 10.1248/bpb1978.10.595 |
| format | Article |
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The compound almost completely inhibited O2- production by a particulate fraction prepared from TPA-treated PMNL at a concentration as low as 250 nM.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Azoles - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Guinea Pigs</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>NADP - metabolism</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - metabolism</subject><subject>Organoselenium Compounds</subject><subject>Pharmacology. 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Antiinflammatory agents</topic><topic>Guinea Pigs</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>NADP - metabolism</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - metabolism</topic><topic>Organoselenium Compounds</topic><topic>Pharmacology. 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| ispartof | Journal of pharmacobio-dynamics, 1987, Vol.10 (10), p.595-597 |
| issn | 0386-846X 1881-1353 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antioxidants - pharmacology Azoles - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Guinea Pigs In Vitro Techniques Medical sciences NADP - metabolism Neutrophils - drug effects Neutrophils - metabolism Organoselenium Compounds Pharmacology. Drug treatments Selenium - pharmacology Superoxides - metabolism |
| title | Inhibition of superoxide, anion production in guinea pig polymorphonuclear leukocytes by a seleno-organic compound, Ebselen |
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