Inhibition of superoxide, anion production in guinea pig polymorphonuclear leukocytes by a seleno-organic compound, Ebselen

Production of superoxide anion (O2-) induced by tetradecanoyl phorbol acetate (TPA) in intact guinea pig polymorphonuclear leukocytes (PMNL) was markedly inhibited by a seleno-organic compound, 2-phenyl-1,2-benzisoselenazol-3(2H)-one (Ebselen), with glutathione peroxidase-like activity. The compound...

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Veröffentlicht in:	Journal of pharmacobio-dynamics 1987, Vol.10 (10), p.595-597
Hauptverfasser:	ICHIKAWA, S, OMURA, K, KATAYAMA, T, OKAMURA, N, OHTSUKA, T, ISHIBASHI, S, MASAYASU, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Azoles - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Guinea Pigs In Vitro Techniques Medical sciences NADP - metabolism Neutrophils - drug effects Neutrophils - metabolism Organoselenium Compounds Pharmacology. Drug treatments Selenium - pharmacology Superoxides - metabolism
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Zusammenfassung:	Production of superoxide anion (O2-) induced by tetradecanoyl phorbol acetate (TPA) in intact guinea pig polymorphonuclear leukocytes (PMNL) was markedly inhibited by a seleno-organic compound, 2-phenyl-1,2-benzisoselenazol-3(2H)-one (Ebselen), with glutathione peroxidase-like activity. The compound almost completely inhibited O2- production by a particulate fraction prepared from TPA-treated PMNL at a concentration as low as 250 nM.
ISSN:	0386-846X 1881-1353
DOI:	10.1248/bpb1978.10.595