Orally Active Squalene Synthase Inhibitors: Bis((acyloxy)alkyl) Prodrugs of the α-Phosphonosulfonic Acid Moiety

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Veröffentlicht in:	Journal of medicinal chemistry 1996-02, Vol.39 (3), p.661-664
Hauptverfasser:	Dickson, John K, Biller, Scott A, Magnin, David R, Petrillo, Edward W, Hillyer, John W, Hsieh, Dolly C, Lan, Shih-Jung, Rinehart, J. Kent, Gregg, Richard E, Harrity, Thomas W, Jolibois, Kern G, Kalinowski, Stephen S, Kunselman, Lori K, Mookhtiar, Kasim A, Ciosek, Carl P
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors General and cellular metabolism. Vitamins Guinea Pigs Hypolipidemic Agents - chemical synthesis Hypolipidemic Agents - chemistry Hypolipidemic Agents - pharmacology Medical sciences Pharmacology. Drug treatments Prodrugs - chemical synthesis Prodrugs - chemistry Prodrugs - pharmacology Rats Sulfonic Acids - chemical synthesis Sulfonic Acids - chemistry Sulfonic Acids - pharmacology
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