Angiogenesis and Tumor Growth

To the Editor: Folkman's article on angiogenesis (Dec. 28 issue) 1 focused on clinical applications, with particular emphasis on the treatment of cancer. There is evidence that angiogenesis is indeed a factor in the progression of human carcinoma, but the extent of its role is in question. 2 Although an intratumoral lymphatic system is usually not well developed in solid tumors, an elaborate system of lymphatic and prelymphatic channels in close proximity to the primary cancer and invasive areas has been reported in breast cancer. 3 It is therefore important to consider the possible impact of lymphagenesis (lymphatic-vessel formation) on the growth and . . .