Secretion of prolactin in response to serotonin requires an intact hypothalamo-pituitary axis in the ewe
The effects on prolactin secretion and the subsequent site of action of serotonin (5-HT) were examined in ovariectomized hypothalamo-pituitary intact (HP-intact) and ovariectomized hypothalamo-pituitary disconnected (HPD) ewes. The administration of 5 mg per animal of 5-HT increased plasma prolactin...
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Veröffentlicht in: | Neuroscience letters 1987-12, Vol.83 (3), p.323-326 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The effects on prolactin secretion and the subsequent site of action of serotonin (5-HT) were examined in ovariectomized hypothalamo-pituitary intact (HP-intact) and ovariectomized hypothalamo-pituitary disconnected (HPD) ewes. The administration of 5 mg per animal of 5-HT increased plasma prolactin concentrations within 20 min by two-three fold in HP-intact ewes, but had no effect in HPD ewes. Injection of vehicle (saline) did not alter plasma prolactin concentrations in either group. These data indicate that 5-HT is involved in the control of prolactin secretion in sheep and that this action is exerted at the level of the hypothalamus and not directly at the pituitary gland. |
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ISSN: | 0304-3940 1872-7972 |
DOI: | 10.1016/0304-3940(87)90108-X |