Studies on Peptides. CLIV. Synthesis of a 36-Residue Peptide Amide Corresponding to the Entire Amino Acid Sequence of Human Pancreatic Polypeptide

A 36-residue peptide corresponding to the entire amino acid sequence of human pancreatic polypeptide (hPP) was synthesized by the solution method. A new Asp derivative, Asp (OMen) [Men = menthyl] was employed. Seven fragments served to construct the peptide backbone of hPP and all the protecting gro...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1987/09/25, Vol.35(9), pp.3585-3596
Hauptverfasser:	SUGIYAMA, NAOKI, FUJII, NOBUTAKA, FUNAKOSHI, SUSUMU, FUNAKOSHI, AKIHIRO, MIYASAKA, KYOKO, AONO, MITSURU, MORIGA, MOTOYUKI, INOUE, KAZUTOMO, KOGIRE, MASAFUMI, SUMI, SHOICHIRO, DOI, RYUICHIRO, TOBE, TAKAYOSHI, YAJIMA, HARUAKI
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Chemistry diphenylsulfide-mediated deprotection Exact sciences and technology hard acid deprotection human pancreatic polypeptide synthesis Humans inhibited pancreatic secretion man Molecular Sequence Data Organic chemistry pancreas pancreatic polypeptide Pancreatic Polypeptide - chemical synthesis peptide synthesis Peptides Peptides - chemical synthesis Preparations and properties Rats soft base trimethylsilyl trifluoromethanesulfonate β-menthylaspartate
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Beschreibung
Zusammenfassung:	A 36-residue peptide corresponding to the entire amino acid sequence of human pancreatic polypeptide (hPP) was synthesized by the solution method. A new Asp derivative, Asp (OMen) [Men = menthyl] was employed. Seven fragments served to construct the peptide backbone of hPP and all the protecting groups employed were cleaved by 2 M trimethylsilyl trifluoromethane-sulfonate-diphenylsulfide/trifluoroacetic acid. The synthetic peptide inhibited protein secretion from rat pancreas.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.35.3585