Verapamil and Lithium in Maintenance Therapy of Manic Patients

A year‐long double‐blind cross‐over study was used to compare the long‐term therapeutic effects of lithium versus verapamil in a group of 20 manic volunteers. Subjects received each medication for six months. Before cross‐over, verapamil patients showed a significant improvement after 60 days, lithi...

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Veröffentlicht in:	Journal of clinical pharmacology 1987-12, Vol.27 (12), p.980-982
Hauptverfasser:	Giannini, A. James, Taraszewski, Robert, Loiselle, Robert H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Bipolar Disorder - drug therapy Bipolar Disorder - psychology Clinical Trials as Topic Double-Blind Method Humans Lithium - therapeutic use Male Medical sciences Miscellaneous Neuropharmacology Pharmacology. Drug treatments Psychiatric Status Rating Scales Random Allocation Verapamil - therapeutic use
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Zusammenfassung:	A year‐long double‐blind cross‐over study was used to compare the long‐term therapeutic effects of lithium versus verapamil in a group of 20 manic volunteers. Subjects received each medication for six months. Before cross‐over, verapamil patients showed a significant improvement after 60 days, lithium‐treated patients after 180 days. After cross‐over, verapamil‐treated subjects showed improvement at day 240. Lithium‐treated patients showed no improvement after cross‐over. The data indicate that verapamil may be effective as an agent in the maintenance treatment of manic patients.
ISSN:	0091-2700 1552-4604
DOI:	10.1002/j.1552-4604.1987.tb05600.x