Response to epirubicin in patients with superficial bladder cancer and expression of the topoisomerase II α and β genes

Biopsies of superficial bladder cancer were analysed to study the relationship between response to epirubicin and the expression of the human topoisomerase II α and β genes. Tissue samples were obtained prior to treatment and a marker tumour was left in the bladder. Transcript levels of both genes w...

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Veröffentlicht in:	International journal of cancer 1996-01, Vol.65 (1), p.63-66
Hauptverfasser:	Davies, Sally L., Popert, Rick, Coptcoat, Malcolm, Hickson, Ian D., Masters, John R. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibiotics, Antineoplastic - therapeutic use Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Carcinoma, Transitional Cell - drug therapy Chemotherapy DNA Topoisomerases, Type II - genetics Enzyme Inhibitors - therapeutic use Epirubicin - therapeutic use Female Gene Expression Regulation, Neoplastic - drug effects Humans Isoenzymes - genetics Male Medical sciences Middle Aged Pharmacology. Drug treatments Urinary Bladder Neoplasms - drug therapy
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Zusammenfassung:	Biopsies of superficial bladder cancer were analysed to study the relationship between response to epirubicin and the expression of the human topoisomerase II α and β genes. Tissue samples were obtained prior to treatment and a marker tumour was left in the bladder. Transcript levels of both genes were generally lower in biopsies taken following treatment failure. Levels of topoisomerase II mRNA were uniformly lower in tumour tissue than in biopsies of normal tissue. © 1996 Wiley‐Liss, Inc.
ISSN:	0020-7136 1097-0215
DOI:	10.1002/(SICI)1097-0215(19960103)65:1<63::AID-IJC11>3.0.CO;2-J