Long-term potentiation induced by physiologically relevant stimulus patterns
Single pulse stimuli were delivered to the Schaffer collaterals in the in vitro hippocampal slice preparation. Local application of bicuculline to the Ca 3 region resulted in a series of population cell bursts in CA 3, resembling the neuronal patterns which occur in the normal, freely moving rat dur...
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Veröffentlicht in: | Brain research 1987-12, Vol.435 (1), p.331-333 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Single pulse stimuli were delivered to the Schaffer collaterals in the in vitro hippocampal slice preparation. Local application of bicuculline to the Ca
3 region resulted in a series of population cell bursts in CA
3, resembling the neuronal patterns which occur in the normal, freely moving rat during hippocampal sharp waves. These bicuculline-induced cell bursts in CA
3 resulted in long-term potentiation (LTP) of the CA
1 response. These findings suggest that the naturally occurring hippocampal sharp waves may reflect events analogous to artificially induced LTP. |
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ISSN: | 0006-8993 1872-6240 |
DOI: | 10.1016/0006-8993(87)91618-0 |