Synthesis of Nocardicins from Penicillins

Synthesis of Nocardicins from Penicillins

A nocardicin derivative was prepared from penicillin G, confirming that nocardicins have the same configuration as penicillins at C-3 of the β-lactam ring.

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1987/08/25, Vol.35(8), pp.3464-3466
Hauptverfasser: NAKAGUCHI, OSAMU, HEMMI, KEIJI, SHIOKAWA, YOICHI, HASHIMOTO, MASASHI, KAMIYA, TAKASHI
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - chemical synthesis
Chemical Phenomena
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Lactams
N-alkylation
nocardicin
Organic chemistry
penicillin
Penicillins - chemical synthesis
Preparations and properties
stereochemistry
unsubstituted monocyclic β-lactam
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Beschreibung
Zusammenfassung:A nocardicin derivative was prepared from penicillin G, confirming that nocardicins have the same configuration as penicillins at C-3 of the β-lactam ring.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.35.3464