Demonstration of human papillomavirus types 6 and 11 in juvenile laryngeal papillomatosis by in-situ DNA hybridization

A study is reported in which an in situ hybridization technique for the demonstration of human papillomavirus (HPV) employing a biotin–streptavidin polyalkaline phosphatase complex has been successfully applied to formalin‐fixed paraffin‐processed tissue obtained from ten patients with juvenile lary...

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Veröffentlicht in:	The Journal of pathology 1987-11, Vol.153 (3), p.245-248
Hauptverfasser:	Terry, R. M., Lewis, F. A., Griffiths, S., Wells, M., Bird, C. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences DNA hybridization DNA, Viral - analysis Human papillomaviruses Human viral diseases Humans Infectious diseases juvenile laryngeal papillomatosis Laryngeal Neoplasms - microbiology Medical sciences Microbiological Techniques Nucleic Acid Hybridization Papilloma - microbiology Papillomaviridae - isolation & purification Viral diseases Viral diseases of the respiratory system and ent viral diseases
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Beschreibung
Zusammenfassung:	A study is reported in which an in situ hybridization technique for the demonstration of human papillomavirus (HPV) employing a biotin–streptavidin polyalkaline phosphatase complex has been successfully applied to formalin‐fixed paraffin‐processed tissue obtained from ten patients with juvenile laryngeal papillomatosis. In all cases, positive results were obtained for either HPV type 6 or 11. Normal vocal cord epithelium was negative.
ISSN:	0022-3417 1096-9896
DOI:	10.1002/path.1711530308