Studies on Peptides. CLII. Hard Acid Deprotecting Procedure for Peptide Synthesis

The use of trimethylsilyl trifluoromethanesulfonate as a peptide deprotecting reagent was examined, together with the role of soft bases employed. A new deprotecting procedure based on the hard acid principle is presented.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1987/08/25, Vol.35(8), pp.3447-3452
Hauptverfasser:	FUJII, NOBUTAKA, OTAKA, AKIRA, IKEMURA, OSAMU, HATANO, MIKA, OKAMACHI, AKIRA, FUNAKOSHI, SUSUMU, SAKURAI, MITSUYA, SHIOIRI, TAKAYUKI, YAJIMA, HARUAKI
Format:	Artikel
Sprache:	eng
Schlagworte:	29Si-NMR chemical shift Chemical Phenomena Chemistry Exact sciences and technology hard acid principle hard-soft acid-base concept human glucosedependent insulinotropic polypeptide synthesis new peptide deprotecting procedure Organic chemistry peptide synthesis Peptides Peptides - chemical synthesis Preparations and properties Spectrophotometry, Ultraviolet thioanisole-mediated deprotection trimethylsilyl methanesulfonate trimethylsilyl trifluoroacetate trimethylsilyl trifluoromethane sulfonate trimethylsilyl trifluoromethanesulfonate
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Beschreibung
Zusammenfassung:	The use of trimethylsilyl trifluoromethanesulfonate as a peptide deprotecting reagent was examined, together with the role of soft bases employed. A new deprotecting procedure based on the hard acid principle is presented.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.35.3447