TDT with covariates and genomic screens with mod scores: Their behavior on simulated data

TDT with covariates and genomic screens with mod scores: Their behavior on simulated data

We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constr...

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Veröffentlicht in:Genetic epidemiology 1995, Vol.12 (6), p.659-664
Hauptverfasser: Rice, John P., Neuman, Rosalind J., Hoshaw, Stacy L., Daw, E. Warwick, Gu, Chi
Format: Artikel
Sprache:eng
Schlagworte:
Computer Simulation
Genetic Testing - methods
Genetics, Population
Genome, Human
Genotype
Humans
linkage analysis
Linkage Disequilibrium
Lod Score
mod score
Models, Genetic
transmission/disequilibrium test
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Zusammenfassung:We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus. © 1995 Wiley‐Liss, Inc.
ISSN:0741-0395
1098-2272
DOI:10.1002/gepi.1370120623