Relaxation of smooth muscle by cardiodilatin/atrial natriuretic peptide is inhibited by cAMP-dependent phosphorylation

Cardiodilatins/atrial natriuretic peptides (CDD/ANP) exhibit a common amino acid sequence: Arg 101-Arg 102-Ser 103-Ser 104. Cyclic AMP-dependent phosphorylation of Ser 104 of atrial peptides with [γ- 32P]ATP enables rapid identification of cardiac hormones. The biological activity of in vitro phosph...

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Veröffentlicht in:	FEBS letters 1987-12, Vol.225 (1), p.251-254
Hauptverfasser:	Gagelmann, M., Hock, D., Forssmann, W.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals aorta Apud cells. Peptide and protein hormones. Growth factors Atrial Natriuretic Factor - metabolism Atrial Natriuretic Factor - pharmacology atrial natriuretic hormone Atrial natriuretic peptide Biological activity Biological and medical sciences Cardiodilatin cyclic AMP Cyclic AMP - pharmacology Fundamental and applied biological sciences. Psychology Muscle Contraction - drug effects Muscle Proteins - pharmacology Muscle Relaxation - drug effects Muscle, Smooth, Vascular - physiology Peptide Fragments - metabolism Peptide Fragments - pharmacology Phosphorylation Protein Kinases - metabolism Rabbits smooth muscle Space life sciences Vascular smooth muscle Vertebrates: endocrinology
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Zusammenfassung:	Cardiodilatins/atrial natriuretic peptides (CDD/ANP) exhibit a common amino acid sequence: Arg 101-Arg 102-Ser 103-Ser 104. Cyclic AMP-dependent phosphorylation of Ser 104 of atrial peptides with [γ- 32P]ATP enables rapid identification of cardiac hormones. The biological activity of in vitro phosphorylated cardiodilatin (CDD-28/α-hANP) is dramatically altered compared to the unphosphorylated peptide: the vasorelaxant effect of cardiodilatin 28 is inhibited upon phosphorylation.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(87)81168-7