Synthesis of heparin fragments: A methyl α-pentaoside with high affinity for antithrombin III

The synthesis is described of the methyl α-glycoside of the pentasaccharide which represents the sequence in heparin responsible for binding and activation of the anticoagulant protein Antithrombin II. It was obtained in a yield much better than that of the previously synthesised pentasaccharide and...

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Veröffentlicht in:	Carbohydrate research 1987-09, Vol.167, p.67-75
Hauptverfasser:	Petitou, Maurice, Duchaussoy, Philippe, Lederman, Isidore, Choay, Jean, Jacquinet, Jean-Claude, Sinaÿ, Pierre, Torri, Giangiacomo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antithrombin III - metabolism Heparin - chemical synthesis Heparin - metabolism Indicators and Reagents Magnetic Resonance Spectroscopy Oligosaccharides - chemical synthesis Oligosaccharides - metabolism Optical Rotation Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	The synthesis is described of the methyl α-glycoside of the pentasaccharide which represents the sequence in heparin responsible for binding and activation of the anticoagulant protein Antithrombin II. It was obtained in a yield much better than that of the previously synthesised pentasaccharide and exhibited the same biological properties.
ISSN:	0008-6215 1873-426X
DOI:	10.1016/0008-6215(87)80268-9