Familial hairy cell leukemia

A mother and son are reported who both developed hairy cell leukemia. The mother aged 74 presented with pancytopenia and responded well to splenectomy. Four years later her son aged 48 presented with pancytopenia; splenectomy was less effective but he improved after treatment with interferon-α. Hist...

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Veröffentlicht in:	Leukemia research 1987, Vol.11 (11), p.1027-1029
Hauptverfasser:	Begley, C.G., Tait, B., Crapper, R.M., Briggs, P.G., Brodie, G.N., Mackay, I.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Female Hairy cell leukemia Hematologic and hematopoietic diseases Humans Interferon Type I - therapeutic use Leukemia, Hairy Cell - genetics Leukemia, Hairy Cell - pathology Leukemia, Hairy Cell - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocyte Count Male Medical sciences Middle Aged Prednisolone - therapeutic use Spleen - pathology Splenectomy
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Zusammenfassung:	A mother and son are reported who both developed hairy cell leukemia. The mother aged 74 presented with pancytopenia and responded well to splenectomy. Four years later her son aged 48 presented with pancytopenia; splenectomy was less effective but he improved after treatment with interferon-α. Histological examination of the splenic tissue in both cases showed changes characteristic of hairy cell leukemia. This is the third report of this rare disease occurring in family members.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/0145-2126(87)90122-6