THE CHRONIC EFFECT OF NITRENDIPINE ON HEART AND REGIONAL BLOOD FLOW IN RENOVASCULAR HYPERTENSIVE RATS

Nitrendipine, a new calcium entry blocker, was administered to renovascular hypertensive rats (2KlC Goldblatt) (RHR, n=8) and sham operated control rats (ShC, n=8) to evaluate the effects on left ventricular hypertrophy and regional blood flow using radioactive microspheres. Nine untreated RHR and 8...

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Veröffentlicht in:	JAPANESE CIRCULATION JOURNAL 1987/09/20, Vol.51(9), pp.1027-1034
Hauptverfasser:	KOBAYASHI, KIMINARI, TARAZI, ROBERT C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive agents Biological and medical sciences Blood Pressure - drug effects Calcium antagonist Cardiac Output - drug effects Cardiomegaly - drug therapy Cardiovascular system Cerebral flow Cerebrovascular Circulation - drug effects Coronary Circulation - drug effects Coronary flow Hypertension, Renovascular - drug therapy Male Medical sciences Nitrendipine - pharmacology Nitrendipine - therapeutic use Pharmacology. Drug treatments Rats Rats, Inbred Strains Renal Circulation - drug effects Renal flow Renovascular hypertension
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Zusammenfassung:	Nitrendipine, a new calcium entry blocker, was administered to renovascular hypertensive rats (2KlC Goldblatt) (RHR, n=8) and sham operated control rats (ShC, n=8) to evaluate the effects on left ventricular hypertrophy and regional blood flow using radioactive microspheres. Nine untreated RHR and 8 untreated ShC served as control groups. After 6 weeks treatment (20 mg/kg subcutaneously, every other day), blood pressure reduced significantly in both RHR and ShC associated with a reduction in total peripheral resistance. Significant reversal of left ventricular hypertrophy was noted in RHR (1278±41 to 1024±19 mg, p
ISSN:	0047-1828 1347-4839
DOI:	10.1253/jcj.51.1027