Cocaine-induced changes in time course of regional cerebral blood volume and transit time as determined by dynamic MR imaging
We examined cocaine‐mediated changes in regional cerebral blood volume (rCBV) and mean transit time (MTT) in central brain structures of rats using functional MR imaging techniques. Changes in MTT and rCBV in animals who had previously been given cocaine depended on the length of time between the la...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 1995-11, Vol.5 (6), p.715-718 |
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| container_title | Journal of magnetic resonance imaging |
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| creator | Li, Ka-Loh Suojanen, James N. |
| description | We examined cocaine‐mediated changes in regional cerebral blood volume (rCBV) and mean transit time (MTT) in central brain structures of rats using functional MR imaging techniques. Changes in MTT and rCBV in animals who had previously been given cocaine depended on the length of time between the last pretreatment injection and the acute injection and seemed to parallel cocaine‐mediated changes in extracellular dopamine concentrations. |
| doi_str_mv | 10.1002/jmri.1880050616 |
| format | Article |
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Changes in MTT and rCBV in animals who had previously been given cocaine depended on the length of time between the last pretreatment injection and the acute injection and seemed to parallel cocaine‐mediated changes in extracellular dopamine concentrations.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.1880050616</identifier><identifier>PMID: 8748491</identifier><language>eng</language><publisher>Baltimore: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Blood Flow Velocity - drug effects ; Blood Flow Velocity - physiology ; Blood Volume - drug effects ; Brain - blood supply ; Cocaine ; Cocaine - pharmacology ; Dopamine - physiology ; Functional MR imaging ; Hemodynamics - drug effects ; Hemodynamics - physiology ; Image Processing, Computer-Assisted ; Magnetic Resonance Angiography - instrumentation ; Magnetic Resonance Imaging, Cine - instrumentation ; Male ; Mean transit time ; Rats ; Rats, Inbred WF ; Regional Blood Flow - drug effects ; Regional Blood Flow - physiology ; Regional cerebral blood volume</subject><ispartof>Journal of magnetic resonance imaging, 1995-11, Vol.5 (6), p.715-718</ispartof><rights>Copyright © 1995 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3826-230aee956cfc00bf0bdd175cba7c4ca504aee021f8e33cddf0bc11229b20f6e33</citedby><cites>FETCH-LOGICAL-c3826-230aee956cfc00bf0bdd175cba7c4ca504aee021f8e33cddf0bc11229b20f6e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.1880050616$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.1880050616$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8748491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Ka-Loh</creatorcontrib><creatorcontrib>Suojanen, James N.</creatorcontrib><title>Cocaine-induced changes in time course of regional cerebral blood volume and transit time as determined by dynamic MR imaging</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>We examined cocaine‐mediated changes in regional cerebral blood volume (rCBV) and mean transit time (MTT) in central brain structures of rats using functional MR imaging techniques. Changes in MTT and rCBV in animals who had previously been given cocaine depended on the length of time between the last pretreatment injection and the acute injection and seemed to parallel cocaine‐mediated changes in extracellular dopamine concentrations.</description><subject>Animals</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Blood Flow Velocity - physiology</subject><subject>Blood Volume - drug effects</subject><subject>Brain - blood supply</subject><subject>Cocaine</subject><subject>Cocaine - pharmacology</subject><subject>Dopamine - physiology</subject><subject>Functional MR imaging</subject><subject>Hemodynamics - drug effects</subject><subject>Hemodynamics - physiology</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Angiography - instrumentation</subject><subject>Magnetic Resonance Imaging, Cine - instrumentation</subject><subject>Male</subject><subject>Mean transit time</subject><subject>Rats</subject><subject>Rats, Inbred WF</subject><subject>Regional Blood Flow - drug effects</subject><subject>Regional Blood Flow - physiology</subject><subject>Regional cerebral blood volume</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFv1DAQhS0EKqVw5oTkE7e0YydOHHGCFd0WdQuqQCAulmNPFpfELnZC2QP_HVdZFXHiNKN5730aPUKeMzhmAPzkeozumEkJIKBm9QNyyATnBReyfph3EGXBJDSPyZOUrgGgbStxQA5kU8mqZYfk9yoY7TwWztvZoKXmm_ZbTNR5OrkRqQlzTEhDTyNuXfB6oAYjdjEv3RCCpT_DMGej9pZOUfvkpiWpE7U4YRwz3tJuR-3O69EZurmibtRb57dPyaNeDwmf7ecR-XT69uPqrLh4vz5fvb4oTCl5XfASNGIratMbgK6HzlrWCNPpxlRGC6iyDJz1EsvSWJsNhjHO245DX-fbEXm5cG9i-DFjmtToksFh0B7DnFTTSJkrg2w8WYwmhpQi9uom5l_jTjFQd4Wru8LV38Jz4sUePXcj2nv_vuGsv1r0Wzfg7n849W5zdf4PvVjSLk346z6t43dVN2Uj1OfLtTp98-HLpv66VpflH_r1n5c</recordid><startdate>199511</startdate><enddate>199511</enddate><creator>Li, Ka-Loh</creator><creator>Suojanen, James N.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199511</creationdate><title>Cocaine-induced changes in time course of regional cerebral blood volume and transit time as determined by dynamic MR imaging</title><author>Li, Ka-Loh ; Suojanen, James N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3826-230aee956cfc00bf0bdd175cba7c4ca504aee021f8e33cddf0bc11229b20f6e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Blood Flow Velocity - physiology</topic><topic>Blood Volume - drug effects</topic><topic>Brain - blood supply</topic><topic>Cocaine</topic><topic>Cocaine - pharmacology</topic><topic>Dopamine - physiology</topic><topic>Functional MR imaging</topic><topic>Hemodynamics - drug effects</topic><topic>Hemodynamics - physiology</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Angiography - instrumentation</topic><topic>Magnetic Resonance Imaging, Cine - instrumentation</topic><topic>Male</topic><topic>Mean transit time</topic><topic>Rats</topic><topic>Rats, Inbred WF</topic><topic>Regional Blood Flow - drug effects</topic><topic>Regional Blood Flow - physiology</topic><topic>Regional cerebral blood volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ka-Loh</creatorcontrib><creatorcontrib>Suojanen, James N.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ka-Loh</au><au>Suojanen, James N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cocaine-induced changes in time course of regional cerebral blood volume and transit time as determined by dynamic MR imaging</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>1995-11</date><risdate>1995</risdate><volume>5</volume><issue>6</issue><spage>715</spage><epage>718</epage><pages>715-718</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>We examined cocaine‐mediated changes in regional cerebral blood volume (rCBV) and mean transit time (MTT) in central brain structures of rats using functional MR imaging techniques. Changes in MTT and rCBV in animals who had previously been given cocaine depended on the length of time between the last pretreatment injection and the acute injection and seemed to parallel cocaine‐mediated changes in extracellular dopamine concentrations.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8748491</pmid><doi>10.1002/jmri.1880050616</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1053-1807 |
| ispartof | Journal of magnetic resonance imaging, 1995-11, Vol.5 (6), p.715-718 |
| issn | 1053-1807 1522-2586 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77882580 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Blood Flow Velocity - drug effects Blood Flow Velocity - physiology Blood Volume - drug effects Brain - blood supply Cocaine Cocaine - pharmacology Dopamine - physiology Functional MR imaging Hemodynamics - drug effects Hemodynamics - physiology Image Processing, Computer-Assisted Magnetic Resonance Angiography - instrumentation Magnetic Resonance Imaging, Cine - instrumentation Male Mean transit time Rats Rats, Inbred WF Regional Blood Flow - drug effects Regional Blood Flow - physiology Regional cerebral blood volume |
| title | Cocaine-induced changes in time course of regional cerebral blood volume and transit time as determined by dynamic MR imaging |
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