Cocaine-induced changes in time course of regional cerebral blood volume and transit time as determined by dynamic MR imaging

We examined cocaine‐mediated changes in regional cerebral blood volume (rCBV) and mean transit time (MTT) in central brain structures of rats using functional MR imaging techniques. Changes in MTT and rCBV in animals who had previously been given cocaine depended on the length of time between the la...

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Veröffentlicht in:	Journal of magnetic resonance imaging 1995-11, Vol.5 (6), p.715-718
Hauptverfasser:	Li, Ka-Loh, Suojanen, James N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Flow Velocity - drug effects Blood Flow Velocity - physiology Blood Volume - drug effects Brain - blood supply Cocaine Cocaine - pharmacology Dopamine - physiology Functional MR imaging Hemodynamics - drug effects Hemodynamics - physiology Image Processing, Computer-Assisted Magnetic Resonance Angiography - instrumentation Magnetic Resonance Imaging, Cine - instrumentation Male Mean transit time Rats Rats, Inbred WF Regional Blood Flow - drug effects Regional Blood Flow - physiology Regional cerebral blood volume
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Beschreibung
Zusammenfassung:	We examined cocaine‐mediated changes in regional cerebral blood volume (rCBV) and mean transit time (MTT) in central brain structures of rats using functional MR imaging techniques. Changes in MTT and rCBV in animals who had previously been given cocaine depended on the length of time between the last pretreatment injection and the acute injection and seemed to parallel cocaine‐mediated changes in extracellular dopamine concentrations.
ISSN:	1053-1807 1522-2586
DOI:	10.1002/jmri.1880050616