Presence of different types of procollagen messenger RNAs in human hepatoma cell lines

Human hepatoma cell lines were shown for the first time to contain various types of procollagen mRNAs. The amounts and types of procollagen mRNAs differed depending on the cell lines. Pro α1(III) and pro α1(IV) collagen mRNAs were present in PLC/PRF/5, a hepatocellular carcinoma cell line, whereas p...

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Veröffentlicht in:	Biochemical and biophysical research communications 1987-10, Vol.148 (2), p.869-875
Hauptverfasser:	Inagaki, Yutaka, Tsunokawa, Youko, Sakamoto, Hiromi, Hirohashi, Setsuo, Kobayashi, Kenichi, Hattori, Nobu, Ramirez, Francesco, Terada, Masaaki, Sugimura, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Carcinoma, Hepatocellular - genetics Cell Line Fibronectins - genetics Genes Humans Liver Neoplasms - genetics Procollagen - genetics RNA, Messenger - genetics RNA, Messenger - isolation & purification Transcription, Genetic
Online-Zugang:	Volltext
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Zusammenfassung:	Human hepatoma cell lines were shown for the first time to contain various types of procollagen mRNAs. The amounts and types of procollagen mRNAs differed depending on the cell lines. Pro α1(III) and pro α1(IV) collagen mRNAs were present in PLC/PRF/5, a hepatocellular carcinoma cell line, whereas pro α1(I), pro α2(I), pro α1(IV) and pro α2(V) collagen genes were transcribed in HuH-7, another hepatocellular carcinoma cell line. In contrast, HepG2 cells derived from hepatoblastoma contained little, if any, mRNAs for these types of procollagens we had examined.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(87)90956-9