Possible Role of Endothelial Thromboxane A2 in the Resting Tone and Contractile Responses to Acetylcholine and Arachidonic Acid in Canine Cerebral Arteries

SUMMARYThe amount of immunoreactive thromboxane B2 (TXB2) released from isolated canine arteries was determined by radioimmunoassay. The amount of TXB2 released from the cerebral, coronary, mesenteric, and saphenous arteries was 47.0 ± 7.2, 4.0 ± 0.6, 4.9 ± 0.5, and 2.7 ± 0.4 pg/mg wet weight tissue...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1987-11, Vol.10 (5), p.517-522
Hauptverfasser:	Shirahase, Hiroaki, Usui, Hachiro, Kurahashi, Kazuyoshi, Fujiwara, Motohatsu, Fukui, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Arachidonic Acid Arachidonic Acids - pharmacology Cerebral Arteries - drug effects Cerebral Arteries - physiology Dogs Endothelium, Vascular - physiology Female In Vitro Techniques Indomethacin - pharmacology Male Methacrylates - pharmacology Radioimmunoassay Thromboxane A2 - analogs & derivatives Thromboxane A2 - pharmacology Thromboxane A2 - physiology Thromboxane-A Synthase - antagonists & inhibitors Vasoconstriction - drug effects
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Zusammenfassung:	SUMMARYThe amount of immunoreactive thromboxane B2 (TXB2) released from isolated canine arteries was determined by radioimmunoassay. The amount of TXB2 released from the cerebral, coronary, mesenteric, and saphenous arteries was 47.0 ± 7.2, 4.0 ± 0.6, 4.9 ± 0.5, and 2.7 ± 0.4 pg/mg wet weight tissue/30 min, respectively. The release of TXB2 from the cerebral artery was decreased to
ISSN:	0160-2446 1533-4023
DOI:	10.1097/00005344-198711000-00004