Controlled evaluation of nabumetone in the treatment of active adult rheumatoid arthritis: Nabumetone versus naproxen double-blind parallel study

Nabumetone is a new nonsteroidal anti-inflammatory agent. Therapy with nabumetone 1,000 mg given at bedtime was compared with naproxen 250 mg given twice daily in a prospective double-blind study of patients with rheumatoid arthritis. Both drugs were found to be efficacious in a comparable fashion....

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Veröffentlicht in:	The American journal of medicine 1987-10, Vol.83 (4), p.55-59
Hauptverfasser:	Vasey, Frank B., Germain, Bernard F., Espinoza, Luis R., Box, Patrick, Bockow, Barry I., Lipani, John A., Mullen, Bernard J., Brodsky, Alan L., Fleischmann, Roy M., Fogari, Robert A., Keller, Michael I., Partridge, Raymond E.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Arthritis, Rheumatoid - drug therapy Butanones - therapeutic use Clinical Trials as Topic Double-Blind Method Female Humans Male Middle Aged Nabumetone Naproxen - therapeutic use Prospective Studies Random Allocation
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Zusammenfassung:	Nabumetone is a new nonsteroidal anti-inflammatory agent. Therapy with nabumetone 1,000 mg given at bedtime was compared with naproxen 250 mg given twice daily in a prospective double-blind study of patients with rheumatoid arthritis. Both drugs were found to be efficacious in a comparable fashion. Both drugs were well tolerated in terms of patient withdrawal rates, which were 5 and 8 percent, respectively. Gastrointestinal side effects were the most commonly encountered problem. Nabumetone holds promise as an important new therapeutic approach in arthritis.
ISSN:	0002-9343 1555-7162
DOI:	10.1016/0002-9343(87)90595-X