Changes of dipole moments in the series of Boc-(ProLeuGly)n-OBzl oligopeptides and their possible explanation. A preliminary survey

It was found that the dipole moments in the series of Boc‐(ProLeuGly)n‐OBzl oligopeptides (n = 1–5) measured in dioxane solution demonstrate a distinct concentration dependence beginning from dodecapeptide. This effect may be connected with the appearance of aggregated (triple‐helical?) structure in conformation equilibrium. The tendency to minimize the dipole moment of the system may be of some importance in the creation of supercoiled structures of polypeptides.