L-735,334, a Novel Sesquiterpenoid Potassium Channel-Agonist from Trichoderma virens

A novel oleic acid ester of the carotane sesquiterpene 14-hydroxy CAF-603 was isolated from Trichoderma virens grown in a solid brown rice-based medium, a solid millet-based medium, or a mannitol-based liquid medium. Its structure was determined on the basis of ms and nmr analysis. It retains distin...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1995-12, Vol.58 (12), p.1822-1828
Hauptverfasser:	Lee, Seok H, Hensens, Otto D, Helms, Gregory L, Liesch, Jerrold M, Zink, Deborah L, Giacobbe, Robert A, Bills, Gerald F, Stevens-Miles, Siobhan, Garcia, Maria L, Schmalhofer, William A, McManus, Owen B, Kaczorowski, Gregory J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Aorta - drug effects Aorta - metabolism Applied microbiology Biological and medical sciences Calcium - physiology Cattle CHEMICAL COMPOSITION COMPOSICION QUIMICA COMPOSITION CHIMIQUE Crystallography, X-Ray ESPAGNE ESPANA ESPECTROMETRIA Fundamental and applied biological sciences. Psychology GLIOCLADIUM GLIOCLADIUM VIRENS In Vitro Techniques INHIBITORS ION ION TRANSPORT IONES IONS Magnetic Resonance Spectroscopy Mass Spectrometry Microbiology MOLECULAR CONFORMATION molecular structure Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism POTASIO POTASSIUM Potassium Channels - agonists Potassium Channels - drug effects Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology SESQUITERPENOIDE SESQUITERPENOIDS SESQUITERPENOS SPAIN SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY Trichoderma - chemistry
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Zusammenfassung:	A novel oleic acid ester of the carotane sesquiterpene 14-hydroxy CAF-603 was isolated from Trichoderma virens grown in a solid brown rice-based medium, a solid millet-based medium, or a mannitol-based liquid medium. Its structure was determined on the basis of ms and nmr analysis. It retains distinct biological activity on the high conductance calcium-activated potassium channel, unlike its analogues 14-hydroxy CAF-603, CAF-603 3-oleate, or CAF-603 3-linoleate.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50126a004