Influence of duodenal slaframine infusion on site of nutrient disappearance from the digestive tract of steers fed a high-concentrate diet

The effect of duodenal slaframine (SF) infusion on site and extent of digestion was determined using four steers equipped with ruminal, duodenal, and ileal cannulas in a 4 X 4 Latin square. A 77% dry-rolled corn diet was provided in 12 equal portions daily at a DMI of 2.26% BW. Slaframine in a 0.9% saline excipient was infused into the duodenum every 12 h with total daily doses of 0, 30, 60, or 90 microgram/kg of BW. Slaframine infusion had no effect on ruminal pH, ruminal NH3 N, or solids and liquids passage rate. Slaframine increased (linear, P 0.10) total tract OM and starch disappearance and digestibility and tended to increase (linear, P