Neonatal Hemochromatosis: Failure of Deferoxamine Therapy

SUMMARYWe describe a premature neonate with severe hepatic dysfunction from birth which progressed to fatal hepatic failure at 3 months of age. The diagnosis of a familial disorder, neonatal hemochromatosis, was made, and therapy was attempted with deferoxamine. Features of iron metabolism are prese...

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Veröffentlicht in:	Journal of pediatric gastroenterology and nutrition 1987-11, Vol.6 (6), p.984-988
Hauptverfasser:	Jonas, Maureen M, Kavveblum, Yosef Aaron, Fojaco, Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Deferoxamine - administration & dosage Deferoxamine - therapeutic use Digestive system Female Hemochromatosis - complications Hemochromatosis - drug therapy Hemochromatosis - genetics Humans Infant, Newborn Iron - metabolism Liver - metabolism Liver - pathology Liver Cirrhosis - etiology Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Medical sciences Pharmacology. Drug treatments
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Zusammenfassung:	SUMMARYWe describe a premature neonate with severe hepatic dysfunction from birth which progressed to fatal hepatic failure at 3 months of age. The diagnosis of a familial disorder, neonatal hemochromatosis, was made, and therapy was attempted with deferoxamine. Features of iron metabolism are presented, and this infantʼs illness is contrasted with other liver diseases of infancy associated with hepatic iron overload.
ISSN:	0277-2116 1536-4801
DOI:	10.1002/j.1536-4801.1987.tb09447.x