A novel subtype of muscarinic receptor identified by homology screening

A novel subtype of muscarinic receptor identified by homology screening

A new member of the protein superfamily of G-protein coupled receptors has been isolated by homology screening. By virtue of its homology with other muscarinic acetylcholine receptors and its ability to bind muscarinic specific antagonists, this muscarinic receptor subtype is designated M4. The M4 m...

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Veröffentlicht in:Biochemical and biophysical research communications 1987-11, Vol.149 (1), p.125-132
Hauptverfasser: Braun, Thomas, Schofield, Peter R., Shivers, Brenda D., Pritchett, Dolan B., Seeburg, Peter H.
Format: Artikel
Sprache:eng
Schlagworte:
acetylcholine
Amino Acid Sequence
Animals
Applied sciences
Base Sequence
brain
Brain - metabolism
DNA - genetics
DNA, Recombinant
Exact sciences and technology
GTP-Binding Proteins - metabolism
Molecular Sequence Data
Nucleic Acid Hybridization
Other techniques and industries
Quinuclidinyl Benzilate - metabolism
Rats
Receptors, Muscarinic - genetics
Receptors, Muscarinic - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sequence Homology, Nucleic Acid
Tissue Distribution
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Zusammenfassung:A new member of the protein superfamily of G-protein coupled receptors has been isolated by homology screening. By virtue of its homology with other muscarinic acetylcholine receptors and its ability to bind muscarinic specific antagonists, this muscarinic receptor subtype is designated M4. The M4 mRNA is preferentially expressed in certain brain regions. The existence of multiple receptor subtypes encoded by distinct genes in the brain has functional implications for the molecular mechanisms underlying information transmission in neuronal networks.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(87)91613-5