MTP-1307, a novel antidiabetic agent, improves the glucose intolerance of viable yellow obese-diabetic mice

MTP-1307 is an oral antidiabetic agent with a unique profile. It improves the glucose intolerance of viable yellow obese-diabetic mice at 25 mg/kg whereas at 300 mg/kg, it only marginally lowers the basal glucose levels of the same mice. This selective activity on exogenous glucose makes MTP-1307 po...

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Veröffentlicht in:	Life sciences (1973) 1987-11, Vol.41 (21), p.2349-2354
1. Verfasser:	Yen, Terence T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences BLOOD COMPOSITION Blood Glucose - metabolism COMPOSICION DE LA SANGRE COMPOSITION DU SANG DIABETE DIABETES Diabetes Mellitus - blood Diabetes Mellitus - drug therapy Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy DRUGS Fasting Glucose Tolerance Test Hormones. Endocrine system HYPOGLYCEMIC AGENTS Hypoglycemic Agents - therapeutic use Kinetics Male Medical sciences MEDICAMENT MEDICAMENTOS MICE Mice, Inbred Strains Mice, Mutant Strains Obesity OVERWEIGHT Pharmacology. Drug treatments Pyrimidines - therapeutic use RATON SOBREPESO SOURIS SURPOIDS Tolbutamide - therapeutic use
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Zusammenfassung:	MTP-1307 is an oral antidiabetic agent with a unique profile. It improves the glucose intolerance of viable yellow obese-diabetic mice at 25 mg/kg whereas at 300 mg/kg, it only marginally lowers the basal glucose levels of the same mice. This selective activity on exogenous glucose makes MTP-1307 potentially a useful agent to treat postprandial glucose intolerance without causing hypoglycemia.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(87)90658-8