Rapid increase in plasma nitrite concentration following intravenous administration of nipradilol

Nipradilol, a β-adrenoceptor antagonist with vasodilator activity, has a structure which contains a NO 2 group. In anesthetized dogs, the time course of the systemic vasodilatation and plasma nitrite (NO − 2) concentration was studied following intravenous administration of nipradilol (1 mg/kg). A f...

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Veröffentlicht in:European journal of pharmacology 1995-11, Vol.286 (2), p.201-204
Hauptverfasser: Adachi, Takeshi, Hori, Shingo, Miyazaki, Koji, Takahashi, Eiichi, Nakagawa, Masahiro, Udagawa, Akira, Hayashi, Nariyuki, Aikawa, Naoki, Ogawa, Satoshi
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Sprache:eng
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Zusammenfassung:Nipradilol, a β-adrenoceptor antagonist with vasodilator activity, has a structure which contains a NO 2 group. In anesthetized dogs, the time course of the systemic vasodilatation and plasma nitrite (NO − 2) concentration was studied following intravenous administration of nipradilol (1 mg/kg). A fall in systemic vascular resistance was observed at 1 min, which was rapidly followed by a significant increase in the plasma NO − 2 concentration. It is indicated that nipradilol exerts systemic vasodilatation via nitric oxide (NO) release in vivo.
ISSN:0014-2999
1879-0712
DOI:10.1016/0014-2999(95)00559-4