Electrophysiological evidence for oxytocin receptors on sympathetic preganglionic neurones — an in vitro study on the neonatal rat

The action of oxytocin (0.01–1 μM) on sympathetic preganglionic neurones was studied by intracellular recording in slices of neonatal rat thoracic spinal cord. In 85% of the cells superfusion induced a slow tetrodotoxin-insensitive depolarization accompanied by the appearance or increase in frequenc...

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Veröffentlicht in:	Brain research 1995-11, Vol.699 (1), p.139-142
Hauptverfasser:	Desaulles, Eric, Reiter, Marie Kathrin, Feltz, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Animals, Newborn Autonomic nervous system Biocytin Dose-Response Relationship, Drug In vitro In Vitro Techniques Intracellular recording Oxytocin - pharmacology Oxytocin receptor Rats Rats, Wistar Slice Spinal cord Spinal Cord - drug effects Sympathetic Nervous System - drug effects Sympathetic preganglionic neuron
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Zusammenfassung:	The action of oxytocin (0.01–1 μM) on sympathetic preganglionic neurones was studied by intracellular recording in slices of neonatal rat thoracic spinal cord. In 85% of the cells superfusion induced a slow tetrodotoxin-insensitive depolarization accompanied by the appearance or increase in frequency of repetitive discharges. Oxytocin also caused some cells to switch from silent neurones to spontaneously active ones. These effects were reversibly blocked by a specific oxytocin antagonist.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(95)01019-R