Comparison of the in vitro activity of levofloxacin and other antimicrobial agents against vancomycin-susceptible and vancomycin resistant Enterococcus species

The in vitro activities of levofloxacin and other antibiotics against 133 clinical isolates of vancomycin-resistant and vancomycin-susceptible enterococci were evaluated. Only 14 (39%) of the vancomycin-susceptible isolates and 11 (11%) of the vancomycin-resistant isolates were susceptible to levofl...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 1995-08, Vol.22 (4), p.349-352
Hauptverfasser:	Hayden, Mary K., Matushek, Marian G., Trenholme, Gordon M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ampicillin - pharmacology Anti-Bacterial Agents - pharmacology Anti-Infective Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Ciprofloxacin - pharmacology Drug Resistance, Microbial Enterococcus - drug effects Levofloxacin Medical sciences Microbial Sensitivity Tests Ofloxacin - pharmacology Penicillins - pharmacology Pharmacology. Drug treatments Vancomycin - pharmacology
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Beschreibung
Zusammenfassung:	The in vitro activities of levofloxacin and other antibiotics against 133 clinical isolates of vancomycin-resistant and vancomycin-susceptible enterococci were evaluated. Only 14 (39%) of the vancomycin-susceptible isolates and 11 (11%) of the vancomycin-resistant isolates were susceptible to levofloxacin. Levofloxacin exhibited a marked inoculum effect for all enterococci tested. These results suggest that levofloxacin may be of limited use in the treatment of serious enterococcal infections.
ISSN:	0732-8893 1879-0070
DOI:	10.1016/0732-8893(95)00144-1