Cardiotonic Flavonoids from Citrus Plants (Rutaceae)

Two flavonoids, 3, 5, 6, 7, 8, 3', 4'-heptamethoxyflavone (HEPTA) and natsudaidain isolated from Citrus plants (Rutaceae), produced a positive inotropic effect (PIE) on guinea-pig papillary muscle. Natsudaidain (pD2 4.98±0.07) was more potent than HEPTA (pD2 4.33±0.08), but the maximum PIE...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1994/11/15, Vol.17(11), pp.1519-1521
Hauptverfasser:	ITOIGAWA, Masataka, TAKEYA, Kazumi, FURUKAWA, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	3, 5, 6, 7, 8, 3', 4'-heptamethoxyflavone Animals Biological and medical sciences Cardiotonic agents Cardiotonic Agents - administration & dosage Cardiotonic Agents - isolation & purification Cardiotonic Agents - pharmacology Cardiovascular system Citrus Citrus - chemistry Dose-Response Relationship, Drug Female flavonoid Flavonoids - administration & dosage Flavonoids - isolation & purification Flavonoids - pharmacology Guinea Pigs Male Medical sciences Methylation Myocardial Contraction - drug effects natsudaidain Papillary Muscles - drug effects Pharmacology. Drug treatments Plant Extracts - administration & dosage Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Leaves - chemistry positive inotropic effect Rats Rutaceae Structure-Activity Relationship Time Factors
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Beschreibung
Zusammenfassung:	Two flavonoids, 3, 5, 6, 7, 8, 3', 4'-heptamethoxyflavone (HEPTA) and natsudaidain isolated from Citrus plants (Rutaceae), produced a positive inotropic effect (PIE) on guinea-pig papillary muscle. Natsudaidain (pD2 4.98±0.07) was more potent than HEPTA (pD2 4.33±0.08), but the maximum PIE of HEPTA was greater than that of natsudaidain. The PIE of HEPTA was completely inhibited by reserpinization of the guinea pig, and partially inhibited by metoprolol and carbachol. The carbachol inhibition was omitted by atropine. The mechanism of PIE of HEPTA is accounted for catecholamine release from cardiac tissue.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.17.1519