Effects of quercetin on Na(+)-K(+)-exchanging ATPase and Ca(2+) Mg(2+)-ATPase in rats

Effects of quercetin on Na(+)-K(+)-exchanging ATPase and Ca(2+) Mg(2+)-ATPase in rats

Quercetin (Que) ig 200 mg.kg-1, qd x 14 d decreased activities of the Na(+)-K(+)-exchanging ATPase (I) of rat brain plasma membranes and heart sarcolemmal and Ca(2+) Mg(2+)-ATPase (II) of heart sarcolemmal membrane. Que 100 mg.kg-1 reduced the activity of I from rat heart sarcolemmal preparation, bu...

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Veröffentlicht in:Zhōngguó yàolĭ xuébào 1994-09, Vol.15 (5), p.414-416
Hauptverfasser: Gu, Z L, Xiao, D, Jin, L Q, Fan, P S, Qian, Z N
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brain - enzymology
Ca(2+) Mg(2+)-ATPase - metabolism
Cell Membrane - enzymology
Male
Myocardium - enzymology
Quercetin - pharmacology
Rats
Rats, Wistar
Sarcolemma - enzymology
Sodium-Potassium-Exchanging ATPase - metabolism
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Zusammenfassung:Quercetin (Que) ig 200 mg.kg-1, qd x 14 d decreased activities of the Na(+)-K(+)-exchanging ATPase (I) of rat brain plasma membranes and heart sarcolemmal and Ca(2+) Mg(2+)-ATPase (II) of heart sarcolemmal membrane. Que 100 mg.kg-1 reduced the activity of I from rat heart sarcolemmal preparation, but had no effect on that from rat brain plasma membranes. The result shows that I of myocardium is more sensitive than that of brain in rat. Que also showed a remarkable inhibitory effect in the II of heart sarcolemma.
ISSN:0253-9756