Animal models of protective immunity in tuberculosis to evaluate candidate vaccines

Animal models of protective immunity in tuberculosis to evaluate candidate vaccines

While the etiology of tuberculosis is well understood, the nature of the protective immune response to the causative mycobacteria has remained a mystery. There is an urgent need to define protective immunity critically, and to develop alternative animal models to evaluate the efficacy of new-generat...

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Veröffentlicht in:Trends in Microbiology 1995-11, Vol.3 (11), p.418-424
Hauptverfasser: Griffin, J.Frank T., Mackintosh, Colin G., Buchan, Glenn S.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
BCG Vaccine - immunology
Disease Models, Animal
Humans
Immunity
Mycobacterium bovis - immunology
Mycobacterium tuberculosis - immunology
Tuberculosis - immunology
Tuberculosis - prevention & control
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Zusammenfassung:While the etiology of tuberculosis is well understood, the nature of the protective immune response to the causative mycobacteria has remained a mystery. There is an urgent need to define protective immunity critically, and to develop alternative animal models to evaluate the efficacy of new-generation vaccines against tuberculosis in a cost-effective way.
ISSN:0966-842X
1878-4380
DOI:10.1016/S0966-842X(00)88994-5