In-vitro activity of LY146032 against Gram-positive isolates from cancer patients

The in-vitro activity of LY146032 was compared with that of other antibiotics against Gram-positive organisms, mostly isolated from cancer patients. LY 146032 inhibited all isolates, including methicillin-resistant Staphylococcus aureus and Streptococcus faecalis, at a concentration of ≤2.0 mg/l. Th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antimicrobial chemotherapy 1987-10, Vol.20 (4), p.497-503
Hauptverfasser:	Saito, Hiroshi, Rolston, Kenneth V. I., Ho, Dah Hsi, LeBlanc, Barbara, Bodey, Gerald P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Daptomycin Gram-Positive Bacteria - drug effects Humans Medical sciences Microbial Sensitivity Tests Neoplasms - microbiology Peptides - pharmacology Pharmacology. Drug treatments
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The in-vitro activity of LY146032 was compared with that of other antibiotics against Gram-positive organisms, mostly isolated from cancer patients. LY 146032 inhibited all isolates, including methicillin-resistant Staphylococcus aureus and Streptococcus faecalis, at a concentration of ≤2.0 mg/l. The MBCs of this new drug were within eight times the MICs for all bacteria tested.
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/20.4.497