DESAMINOANTHRACYCLINES FROM THE ANTIBIOTIC COMPLEX CICLAMYCIN
Ciclamycin, an antibiotic complex produced by Streptomyces capoamus , showed highly inhibitory activity against experimental tumors. By early investigations on chemical composition eta - and epsilon -pyrromycinone were identified as aglycone constituents. Further work on the glycosidic part of the c...
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| Veröffentlicht in: | Journal of antibiotics 1987/09/25, Vol.40(9), pp.1335-1338 |
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| container_issue | 9 |
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| container_title | Journal of antibiotics |
| container_volume | 40 |
| creator | BIEBER, LOTHAR W. ÁLVARO A. DA SILVA FILHO MÉLLO, JOSÉ F. DE LIMA, OSWALDO G. DE NASCIMENTO, MARCIA S. DO VEITH, HANS J. SAAL, WOLFGANG VON DER |
| description | Ciclamycin, an antibiotic complex produced by Streptomyces capoamus , showed highly inhibitory activity against experimental tumors. By early investigations on chemical composition eta - and epsilon -pyrromycinone were identified as aglycone constituents. Further work on the glycosidic part of the complex showed that three major components, ciclamycins 1, 5 and 6 are identical with cinerubine B, cinerubine A and pyrromycin, respectively, and that one of the minor components, ciclamycin 2, is 5'''-epi-cinerubine B. This report describes the structure elucidation of two more components of the ciclamycin complex. |
| doi_str_mv | 10.7164/antibiotics.40.1335 |
| format | Article |
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DA SILVA FILHO ; MÉLLO, JOSÉ F. DE ; LIMA, OSWALDO G. DE ; NASCIMENTO, MARCIA S. DO ; VEITH, HANS J. ; SAAL, WOLFGANG VON DER</creator><creatorcontrib>BIEBER, LOTHAR W. ; ÁLVARO A. DA SILVA FILHO ; MÉLLO, JOSÉ F. DE ; LIMA, OSWALDO G. DE ; NASCIMENTO, MARCIA S. DO ; VEITH, HANS J. ; SAAL, WOLFGANG VON DER</creatorcontrib><description>Ciclamycin, an antibiotic complex produced by Streptomyces capoamus , showed highly inhibitory activity against experimental tumors. By early investigations on chemical composition eta - and epsilon -pyrromycinone were identified as aglycone constituents. Further work on the glycosidic part of the complex showed that three major components, ciclamycins 1, 5 and 6 are identical with cinerubine B, cinerubine A and pyrromycin, respectively, and that one of the minor components, ciclamycin 2, is 5'''-epi-cinerubine B. This report describes the structure elucidation of two more components of the ciclamycin complex.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.40.1335</identifier><identifier>PMID: 3500159</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Antibiotics, Antineoplastic - analysis ; Antibiotics, Antineoplastic - therapeutic use ; Biological and medical sciences ; General pharmacology ; Magnetic Resonance Spectroscopy ; Medical sciences ; Naphthacenes - analysis ; Naphthacenes - therapeutic use ; Neoplasms, Experimental - drug therapy ; Pharmacology. Drug treatments ; Physicochemical properties. 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DA SILVA FILHO</creatorcontrib><creatorcontrib>MÉLLO, JOSÉ F. DE</creatorcontrib><creatorcontrib>LIMA, OSWALDO G. DE</creatorcontrib><creatorcontrib>NASCIMENTO, MARCIA S. DO</creatorcontrib><creatorcontrib>VEITH, HANS J.</creatorcontrib><creatorcontrib>SAAL, WOLFGANG VON DER</creatorcontrib><title>DESAMINOANTHRACYCLINES FROM THE ANTIBIOTIC COMPLEX CICLAMYCIN</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Ciclamycin, an antibiotic complex produced by Streptomyces capoamus , showed highly inhibitory activity against experimental tumors. By early investigations on chemical composition eta - and epsilon -pyrromycinone were identified as aglycone constituents. Further work on the glycosidic part of the complex showed that three major components, ciclamycins 1, 5 and 6 are identical with cinerubine B, cinerubine A and pyrromycin, respectively, and that one of the minor components, ciclamycin 2, is 5'''-epi-cinerubine B. This report describes the structure elucidation of two more components of the ciclamycin complex.</description><subject>Antibiotics, Antineoplastic - analysis</subject><subject>Antibiotics, Antineoplastic - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Naphthacenes - analysis</subject><subject>Naphthacenes - therapeutic use</subject><subject>Neoplasms, Experimental - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemical properties. Structure-activity relationships</subject><subject>Streptomyces - analysis</subject><subject>Troleandomycin - analysis</subject><subject>Troleandomycin - therapeutic use</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1Lw0AQhhdRaq3-AhFyEG-ps93d7O7BQ1xTG0gaaSvoKWySjaakH2bTg__eSEvx5mUG5n0YhnkQusYw5Nij93rdVlm1aavcDikMMSHsBPWxENjF1JOnqA8wwq4QIzhHF9YuAQgnXPRQjzAAzGQfPTwFcz8Op4k_XUxmvnpXUTgN5s54lsTOYhI43Tx8DJNFqByVxC9R8OaoUEV-_K7C6SU6K3VtzdWhD9DrOFioiRslz6HyI3fZ3dS6AjLKgTLiZYJRXmJBABcZeJxpmuOc5KwgmDHDpcwMmGIkcVGUUPCSioxkZIDu9nu3zeZrZ2ybriqbm7rWa7PZ2ZRzAZJQ718QU0Eox6wDbw7gLluZIt021Uo33-nhMV1-e8i1zXVdNnqdV_aIcSIlZbTDoj22tK3-MMdcN52V2qR_FGHpiZRCKvfl19YRyz91k5o1-QEwi4iL</recordid><startdate>19870901</startdate><enddate>19870901</enddate><creator>BIEBER, LOTHAR W.</creator><creator>ÁLVARO A. DA SILVA FILHO</creator><creator>MÉLLO, JOSÉ F. DE</creator><creator>LIMA, OSWALDO G. DE</creator><creator>NASCIMENTO, MARCIA S. DO</creator><creator>VEITH, HANS J.</creator><creator>SAAL, WOLFGANG VON DER</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19870901</creationdate><title>DESAMINOANTHRACYCLINES FROM THE ANTIBIOTIC COMPLEX CICLAMYCIN</title><author>BIEBER, LOTHAR W. ; ÁLVARO A. DA SILVA FILHO ; MÉLLO, JOSÉ F. DE ; LIMA, OSWALDO G. DE ; NASCIMENTO, MARCIA S. DO ; VEITH, HANS J. ; SAAL, WOLFGANG VON DER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j335t-80b4704536b8547f18301db0675a4c1c3c5d3155e799be0ed291ddf0d7f48b3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Antibiotics, Antineoplastic - analysis</topic><topic>Antibiotics, Antineoplastic - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>General pharmacology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Naphthacenes - analysis</topic><topic>Naphthacenes - therapeutic use</topic><topic>Neoplasms, Experimental - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemical properties. 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DA SILVA FILHO</au><au>MÉLLO, JOSÉ F. DE</au><au>LIMA, OSWALDO G. DE</au><au>NASCIMENTO, MARCIA S. DO</au><au>VEITH, HANS J.</au><au>SAAL, WOLFGANG VON DER</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DESAMINOANTHRACYCLINES FROM THE ANTIBIOTIC COMPLEX CICLAMYCIN</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1987-09-01</date><risdate>1987</risdate><volume>40</volume><issue>9</issue><spage>1335</spage><epage>1338</epage><pages>1335-1338</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Ciclamycin, an antibiotic complex produced by Streptomyces capoamus , showed highly inhibitory activity against experimental tumors. By early investigations on chemical composition eta - and epsilon -pyrromycinone were identified as aglycone constituents. 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| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1987/09/25, Vol.40(9), pp.1335-1338 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | MEDLINE; J-STAGE日本語サイト (Free Access) |
| subjects | Antibiotics, Antineoplastic - analysis Antibiotics, Antineoplastic - therapeutic use Biological and medical sciences General pharmacology Magnetic Resonance Spectroscopy Medical sciences Naphthacenes - analysis Naphthacenes - therapeutic use Neoplasms, Experimental - drug therapy Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Streptomyces - analysis Troleandomycin - analysis Troleandomycin - therapeutic use |
| title | DESAMINOANTHRACYCLINES FROM THE ANTIBIOTIC COMPLEX CICLAMYCIN |
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