DESAMINOANTHRACYCLINES FROM THE ANTIBIOTIC COMPLEX CICLAMYCIN

Ciclamycin, an antibiotic complex produced by Streptomyces capoamus , showed highly inhibitory activity against experimental tumors. By early investigations on chemical composition eta - and epsilon -pyrromycinone were identified as aglycone constituents. Further work on the glycosidic part of the c...

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Veröffentlicht in:	Journal of antibiotics 1987/09/25, Vol.40(9), pp.1335-1338
Hauptverfasser:	BIEBER, LOTHAR W., ÁLVARO A. DA SILVA FILHO, MÉLLO, JOSÉ F. DE, LIMA, OSWALDO G. DE, NASCIMENTO, MARCIA S. DO, VEITH, HANS J., SAAL, WOLFGANG VON DER
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - analysis Antibiotics, Antineoplastic - therapeutic use Biological and medical sciences General pharmacology Magnetic Resonance Spectroscopy Medical sciences Naphthacenes - analysis Naphthacenes - therapeutic use Neoplasms, Experimental - drug therapy Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Streptomyces - analysis Troleandomycin - analysis Troleandomycin - therapeutic use
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Zusammenfassung:	Ciclamycin, an antibiotic complex produced by Streptomyces capoamus , showed highly inhibitory activity against experimental tumors. By early investigations on chemical composition eta - and epsilon -pyrromycinone were identified as aglycone constituents. Further work on the glycosidic part of the complex showed that three major components, ciclamycins 1, 5 and 6 are identical with cinerubine B, cinerubine A and pyrromycin, respectively, and that one of the minor components, ciclamycin 2, is 5'''-epi-cinerubine B. This report describes the structure elucidation of two more components of the ciclamycin complex.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.40.1335