ENHANCEMENT OF THE INTESTINAL ABSORPTION OF A CYCLOSPORINE DERIVATIVE BY MILK FAT GLOBULE MEMBRANE

A cyclosporine derivative, dihydrocyclosporine D, was used for the evaluation of milk fat globule membrane (MFGM) as an emulsifier of lipophilic cyclopeptides. As compared with olive oil formulation, MFGM emulsion significantly enhanced the blood and lymphatic fluid concentrations of the cyclosporin...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1994/11/15, Vol.17(11), pp.1526-1528
Hauptverfasser:	SATO, Hitoshi, LIU, HongXing, ADACHI, Isao, UENO, Masaharu, LEMAIRE, Michel, HORIKOSHI, Isamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences cyclosporine derivative Cyclosporins - administration & dosage Cyclosporins - blood Cyclosporins - pharmacokinetics Dietary Fats, Unsaturated - metabolism drug delivery system Drug Delivery Systems Duodenum - drug effects Emulsions Fats - chemistry Fats - metabolism Fats, Unsaturated - chemistry Immunomodulators Intestinal Absorption - drug effects intestinal drug absorption Male Medical sciences Membrane Glycoproteins - pharmacology Micelles Milk - metabolism milk fat globule membrane (MFGM) Mucin-1 Mucins - pharmacology Olive Oil Pharmacology. Drug treatments Plant Oils - chemistry Plant Oils - metabolism Rats Rats, Wistar
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Zusammenfassung:	A cyclosporine derivative, dihydrocyclosporine D, was used for the evaluation of milk fat globule membrane (MFGM) as an emulsifier of lipophilic cyclopeptides. As compared with olive oil formulation, MFGM emulsion significantly enhanced the blood and lymphatic fluid concentrations of the cyclosporine derivative after intraduodenal dosing in rats. Thus, it was suggested that MFGM can be used as an intestinal absorption enhancer of cyclosporines.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.17.1526