The effect of caffeine on prostaglandin output from the perfused mesenteric vascular bed of the rat

Caffeine significantly ( p < 0.05) increased the output of prostacyclin (PGI 2) from the perfused rat mesenteric vascular bed. The outputs of PGE 2 and PGF 2α were also increased by caffeine. This stimulatory response to caffeine did not show rapid desensitization. Ryanodine also increased PG out...

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Veröffentlicht in:	Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 1994-12, Vol.51 (6), p.415-418
Hauptverfasser:	Naderali, E.K., Poyser, N.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Ketoprostaglandin F1 alpha - metabolism Angina Pectoris - physiopathology Animals Biological and medical sciences Caffeine - administration & dosage Caffeine - pharmacology Dinoprost - metabolism Dinoprostone - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Epoprostenol - metabolism Fundamental and applied biological sciences. Psychology Male Mesenteric Arteries - drug effects Mesenteric Arteries - metabolism Mesenteric Veins - drug effects Mesenteric Veins - metabolism Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Perfusion Prostaglandins - metabolism Prostaglandins. Arachidonic acid metabolites Rats Ryanodine - pharmacology Stimulation, Chemical Vertebrates: endocrinology
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