The effect of caffeine on prostaglandin output from the perfused mesenteric vascular bed of the rat

Caffeine significantly ( p < 0.05) increased the output of prostacyclin (PGI 2) from the perfused rat mesenteric vascular bed. The outputs of PGE 2 and PGF 2α were also increased by caffeine. This stimulatory response to caffeine did not show rapid desensitization. Ryanodine also increased PG out...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 1994-12, Vol.51 (6), p.415-418
Hauptverfasser:	Naderali, E.K., Poyser, N.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Ketoprostaglandin F1 alpha - metabolism Angina Pectoris - physiopathology Animals Biological and medical sciences Caffeine - administration & dosage Caffeine - pharmacology Dinoprost - metabolism Dinoprostone - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Epoprostenol - metabolism Fundamental and applied biological sciences. Psychology Male Mesenteric Arteries - drug effects Mesenteric Arteries - metabolism Mesenteric Veins - drug effects Mesenteric Veins - metabolism Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Perfusion Prostaglandins - metabolism Prostaglandins. Arachidonic acid metabolites Rats Ryanodine - pharmacology Stimulation, Chemical Vertebrates: endocrinology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Caffeine significantly ( p < 0.05) increased the output of prostacyclin (PGI 2) from the perfused rat mesenteric vascular bed. The outputs of PGE 2 and PGF 2α were also increased by caffeine. This stimulatory response to caffeine did not show rapid desensitization. Ryanodine also increased PG output, suggesting that caffeine may be acting via the stimulation of a ryanodine receptor. The increased production of a vasodilator such as PGI 2 from blood vessels following exposure to caffeine may explain why caffeine has a beneficial effect in angina.
ISSN:	0952-3278 1532-2823
DOI:	10.1016/0952-3278(94)90058-2