Apiosporamide, a New Antifungal Agent from the Coprophilous Fungus Apiospora montagnei

Bioassay-guided fractionation of an EtOAc extract from the mycelium of the coprophilous fungus Apiospora montagnei has furnished a new antifungal metabolite, named apiosporamide [1], and the known dihydroisocoumarin cis-(3R,4R)-4-hydroxymellein [4]. The structure of 1 was assigned on the basis of HM...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1994-12, Vol.57 (12), p.1696-1702
Hauptverfasser:	Alfatafta, Ali A, Gloer, James B, Scott, James A, Malloch, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Antifungal Agents - isolation & purification Antifungal Agents - pharmacology chemical composition composicion quimica composition chimique Cyclohexanols - isolation & purification Cyclohexanols - pharmacology dothideales espectrometria fongicide fungicidas fungicides Magnetic Resonance Spectroscopy metabolite metabolites metabolitos micelio Microbial Sensitivity Tests mycelium Pyridones - isolation & purification Pyridones - pharmacology spectrometrie spectrometry Xylariales - chemistry
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Beschreibung
Zusammenfassung:	Bioassay-guided fractionation of an EtOAc extract from the mycelium of the coprophilous fungus Apiospora montagnei has furnished a new antifungal metabolite, named apiosporamide [1], and the known dihydroisocoumarin cis-(3R,4R)-4-hydroxymellein [4]. The structure of 1 was assigned on the basis of HMBC, HMQC, NOESY, and hrms data. Elucidation of the structure was complicated by the fact that several nmr signals appeared only under certain conditions.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50114a012