Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats

Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats. Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant pha...

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Veröffentlicht in:	Kidney international 1994-12, Vol.46 (6), p.1528-1532
Hauptverfasser:	Whitworth, Caroline E., Fleming, Stewart, Cumming, Allan D., Morton, James J., Burns, Nicola J.T., Williams, Brent C., Mullins, John J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Blood Pressure - genetics Disease Models, Animal Female Heterozygote Humans Hypertension, Malignant - etiology Hypertension, Malignant - genetics Hypertension, Malignant - pathology Kidney - pathology Male Phenotype Rats Rats, Inbred Lew Rats, Sprague-Dawley Sodium, Dietary - administration & dosage
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Beschreibung
Zusammenfassung:	Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats. Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.
ISSN:	0085-2538 1523-1755
DOI:	10.1038/ki.1994.437