HYPERPROLIFERATION OF AORTIC SMOOTH MUSCLE CELLS AND FIBROBLASTS FROM YOUNG SHR RATS IS NOT SHARED BY ENDOTHELIAL CELLS

HYPERPROLIFERATION OF AORTIC SMOOTH MUSCLE CELLS AND FIBROBLASTS FROM YOUNG SHR RATS IS NOT SHARED BY ENDOTHELIAL CELLS

SUMMARY 1. To study the hypertensive genotypic influence on growth kinetics of the three aortic wall cell types. 2. Using young spontaneously hypertensive (SHR) and Wistar‐Kyoto (WKY) rats weighing 160–180 g, we compared the proliferative properties of endothelial cells (EC), smooth muscle cells (SM...

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Veröffentlicht in:Clinical and experimental pharmacology & physiology 1994-12, Vol.21 (12), p.981-989
Hauptverfasser: Battle, Thierry, Arnal, Jean-François, Michel, Jean-Baptiste
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Aorta, Thoracic - pathology
Cell Division - physiology
Cells, Cultured
co-cultures
endothelial cells
Endothelium, Vascular - metabolism
Endothelium, Vascular - pathology
extracellular matrix
Extracellular Matrix - metabolism
fibroblasts
Fibroblasts - physiology
Hypertension - genetics
Hypertension - pathology
Muscle, Smooth, Vascular - metabolism
Muscle, Smooth, Vascular - pathology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
smooth muscle cells
Thymidine - metabolism
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Zusammenfassung:SUMMARY 1. To study the hypertensive genotypic influence on growth kinetics of the three aortic wall cell types. 2. Using young spontaneously hypertensive (SHR) and Wistar‐Kyoto (WKY) rats weighing 160–180 g, we compared the proliferative properties of endothelial cells (EC), smooth muscle cells (SMC) and fibroblasts that were isolated from the thoracic aorta of each strain and cultured. Growth‐arrested cells were exposed to P
ISSN:0305-1870
1440-1681
DOI:10.1111/j.1440-1681.1994.tb02660.x