Effect of fedotozine on the cardiovascular pain reflex induced by distension of the irritated colon in the anesthetized rat

The effect of fedotozine was evaluated in a model of colonic hypersensibility to balloon distension in anesthetized rats. Acetic acid (0.6%, intracolonically) significantly enhanced the hypotension reflex response to colonic distension ( P

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Veröffentlicht in:	European journal of pharmacology 1994-12, Vol.271 (2), p.245-251
Hauptverfasser:	Langlois, Annik, Diop, Laurent, Rivière, Pierre J.M., Pascaud, Xavier, Junien, Jean-Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer Acetates Acetic Acid Amino Acid Sequence Analgesics Anesthesia Animals Benzyl Compounds - pharmacology Biological and medical sciences Blood Pressure - drug effects Colon - drug effects Colon - physiology Colonic hypersensitivity Dose-Response Relationship, Drug Fedotozine Male Medical sciences Molecular Sequence Data Neuropharmacology Pain - physiopathology Pharmacology. Drug treatments Propylamines - pharmacology Pyrroles - pharmacology Pyrrolidines - pharmacology Rats Rats, Sprague-Dawley Reflex - drug effects Thiophenes - pharmacology Visceral pain κ-Opioid receptor μ-Opioid receptor
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Beschreibung
Zusammenfassung:	The effect of fedotozine was evaluated in a model of colonic hypersensibility to balloon distension in anesthetized rats. Acetic acid (0.6%, intracolonically) significantly enhanced the hypotension reflex response to colonic distension ( P
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(94)90780-3