ANTIMICROBIAL ACTIVITIES OF CLAVULANIC ACID/TICARCILLIN AGAINST CLINICAL ISOLATES
In order to investigate antimicrobial activities of clavulanic acid/ticarcillin (CVA/TIPC) against Escherichia coli, Enterobacter spp. and Pseudomonas aeruginosa in 1992 and 1994, β-lactamase activities were analyzed and minimum inhibitory concentrations (MICs) were determined including those of the...
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| Veröffentlicht in: | Japanese journal of antibiotics 1995/12/25, Vol.48(12), pp.1899-1905 |
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| container_end_page | 1905 |
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| container_issue | 12 |
| container_start_page | 1899 |
| container_title | Japanese journal of antibiotics |
| container_volume | 48 |
| creator | KOGUCHI, MASAMI SUZUKI, YUMIKO TANAKA, SETSUKO FUKAYAMA, SHIGEMI ISHIHARA, RIKA DEGUCH, KOICHI ODA, SEIJI NAKANE, YUTAKA FUKUMOTO, TORAO |
| description | In order to investigate antimicrobial activities of clavulanic acid/ticarcillin (CVA/TIPC) against Escherichia coli, Enterobacter spp. and Pseudomonas aeruginosa in 1992 and 1994, β-lactamase activities were analyzed and minimum inhibitory concentrations (MICs) were determined including those of the control drugs. The results are as follows; 1. Compared to a report in 1980, the MIC distributions of CVA/TIPC against E. coli and P. aeruginosa did not show large differences. We found, however, that CVA/TIPC-resistant strains increased among Enterobacter spp. 2. Almost all of CVA/TIPC-resistant strains of Enterobacter spp. were also resistant to cephems and new quinolones, thus they were multiple drug resistant. 3. CVA/TIPC showed strong antimicrobial activities aga inst penicillinase producing E. coli. |
| doi_str_mv | 10.11553/antibiotics1968b.48.1899 |
| format | Article |
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The results are as follows; 1. Compared to a report in 1980, the MIC distributions of CVA/TIPC against E. coli and P. aeruginosa did not show large differences. We found, however, that CVA/TIPC-resistant strains increased among Enterobacter spp. 2. Almost all of CVA/TIPC-resistant strains of Enterobacter spp. were also resistant to cephems and new quinolones, thus they were multiple drug resistant. 3. CVA/TIPC showed strong antimicrobial activities aga inst penicillinase producing E. coli.</description><identifier>ISSN: 0368-2781</identifier><identifier>EISSN: 2186-5477</identifier><identifier>DOI: 10.11553/antibiotics1968b.48.1899</identifier><identifier>PMID: 8587164</identifier><language>jpn</language><publisher>Japan: Japan Antibiotics Research Association</publisher><subject>Bacterial Infections - microbiology ; beta-Lactamase Inhibitors ; Clavulanic Acid ; Clavulanic Acids - pharmacology ; Drug Combinations ; Drug Resistance, Microbial ; Drug Therapy, Combination - pharmacology ; Enterobacter - drug effects ; Enterobacter - isolation & purification ; Escherichia coli - drug effects ; Escherichia coli - isolation & purification ; Humans ; Penicillins - pharmacology ; Pseudomonas aeruginosa - drug effects ; Pseudomonas aeruginosa - isolation & purification ; Ticarcillin - pharmacology</subject><ispartof>The Japanese Journal of Antibiotics, 1995/12/25, Vol.48(12), pp.1899-1905</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8587164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOGUCHI, MASAMI</creatorcontrib><creatorcontrib>SUZUKI, YUMIKO</creatorcontrib><creatorcontrib>TANAKA, SETSUKO</creatorcontrib><creatorcontrib>FUKAYAMA, SHIGEMI</creatorcontrib><creatorcontrib>ISHIHARA, RIKA</creatorcontrib><creatorcontrib>DEGUCH, KOICHI</creatorcontrib><creatorcontrib>ODA, SEIJI</creatorcontrib><creatorcontrib>NAKANE, YUTAKA</creatorcontrib><creatorcontrib>FUKUMOTO, TORAO</creatorcontrib><title>ANTIMICROBIAL ACTIVITIES OF CLAVULANIC ACID/TICARCILLIN AGAINST CLINICAL ISOLATES</title><title>Japanese journal of antibiotics</title><addtitle>Jpn. J. Antibiotics</addtitle><description>In order to investigate antimicrobial activities of clavulanic acid/ticarcillin (CVA/TIPC) against Escherichia coli, Enterobacter spp. and Pseudomonas aeruginosa in 1992 and 1994, β-lactamase activities were analyzed and minimum inhibitory concentrations (MICs) were determined including those of the control drugs. The results are as follows; 1. Compared to a report in 1980, the MIC distributions of CVA/TIPC against E. coli and P. aeruginosa did not show large differences. We found, however, that CVA/TIPC-resistant strains increased among Enterobacter spp. 2. Almost all of CVA/TIPC-resistant strains of Enterobacter spp. were also resistant to cephems and new quinolones, thus they were multiple drug resistant. 3. CVA/TIPC showed strong antimicrobial activities aga inst penicillinase producing E. coli.</description><subject>Bacterial Infections - microbiology</subject><subject>beta-Lactamase Inhibitors</subject><subject>Clavulanic Acid</subject><subject>Clavulanic Acids - pharmacology</subject><subject>Drug Combinations</subject><subject>Drug Resistance, Microbial</subject><subject>Drug Therapy, Combination - pharmacology</subject><subject>Enterobacter - drug effects</subject><subject>Enterobacter - isolation & purification</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - isolation & purification</subject><subject>Humans</subject><subject>Penicillins - pharmacology</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Pseudomonas aeruginosa - isolation & purification</subject><subject>Ticarcillin - pharmacology</subject><issn>0368-2781</issn><issn>2186-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE9PwjAYhxujQYJ8BJN58TZY_2xtj3UCNqlbZIPr0o1ORwboOg5-e6sQDl7e9_A87-9NfgA8wGACYRjiqd73Tdkc-qaykEesnBA2gYzzKzBEkEV-SCi9BsMAR8xHlMFbMLa2KQMMKUMuYgAGLGQURmQI3kSSy1cZL9MnKZQn4lyuZS5nmZfOvViJ9UqJRMYOyOdpLmOxjKVSMvHEQsgky50jHXenMkuVyGfZHbipdWvN-LxHYDWf5fGLr9LFr-hvIQ96vw4IQhxHRFPNwzrYBIxgDCOGTKgJgrxGFDNMq4qzsow2MECY4BrVvKIGVSUegcdT7md3-Doa2xe7xlambfXeHI62oJRyxtyLEbg_i8dyZzbFZ9fsdPddnDtwXJ341vb63Vy47lzDrSn-110QVkD0N13pF6360F1h9vgHllR19w</recordid><startdate>199512</startdate><enddate>199512</enddate><creator>KOGUCHI, MASAMI</creator><creator>SUZUKI, YUMIKO</creator><creator>TANAKA, SETSUKO</creator><creator>FUKAYAMA, SHIGEMI</creator><creator>ISHIHARA, RIKA</creator><creator>DEGUCH, KOICHI</creator><creator>ODA, SEIJI</creator><creator>NAKANE, YUTAKA</creator><creator>FUKUMOTO, TORAO</creator><general>Japan Antibiotics Research Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199512</creationdate><title>ANTIMICROBIAL ACTIVITIES OF CLAVULANIC ACID/TICARCILLIN AGAINST CLINICAL ISOLATES</title><author>KOGUCHI, MASAMI ; SUZUKI, YUMIKO ; TANAKA, SETSUKO ; FUKAYAMA, SHIGEMI ; ISHIHARA, RIKA ; DEGUCH, KOICHI ; ODA, SEIJI ; NAKANE, YUTAKA ; FUKUMOTO, TORAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j190t-f04229364a7a95f0d084331682e5a4219f273837cc98bb6d102343f2f9c7e2cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1995</creationdate><topic>Bacterial Infections - microbiology</topic><topic>beta-Lactamase Inhibitors</topic><topic>Clavulanic Acid</topic><topic>Clavulanic Acids - pharmacology</topic><topic>Drug Combinations</topic><topic>Drug Resistance, Microbial</topic><topic>Drug Therapy, Combination - pharmacology</topic><topic>Enterobacter - drug effects</topic><topic>Enterobacter - isolation & purification</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - isolation & purification</topic><topic>Humans</topic><topic>Penicillins - pharmacology</topic><topic>Pseudomonas aeruginosa - drug effects</topic><topic>Pseudomonas aeruginosa - isolation & purification</topic><topic>Ticarcillin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOGUCHI, MASAMI</creatorcontrib><creatorcontrib>SUZUKI, YUMIKO</creatorcontrib><creatorcontrib>TANAKA, SETSUKO</creatorcontrib><creatorcontrib>FUKAYAMA, SHIGEMI</creatorcontrib><creatorcontrib>ISHIHARA, RIKA</creatorcontrib><creatorcontrib>DEGUCH, KOICHI</creatorcontrib><creatorcontrib>ODA, SEIJI</creatorcontrib><creatorcontrib>NAKANE, YUTAKA</creatorcontrib><creatorcontrib>FUKUMOTO, TORAO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOGUCHI, MASAMI</au><au>SUZUKI, YUMIKO</au><au>TANAKA, SETSUKO</au><au>FUKAYAMA, SHIGEMI</au><au>ISHIHARA, RIKA</au><au>DEGUCH, KOICHI</au><au>ODA, SEIJI</au><au>NAKANE, YUTAKA</au><au>FUKUMOTO, TORAO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ANTIMICROBIAL ACTIVITIES OF CLAVULANIC ACID/TICARCILLIN AGAINST CLINICAL ISOLATES</atitle><jtitle>Japanese journal of antibiotics</jtitle><addtitle>Jpn. J. Antibiotics</addtitle><date>1995-12</date><risdate>1995</risdate><volume>48</volume><issue>12</issue><spage>1899</spage><epage>1905</epage><pages>1899-1905</pages><issn>0368-2781</issn><eissn>2186-5477</eissn><abstract>In order to investigate antimicrobial activities of clavulanic acid/ticarcillin (CVA/TIPC) against Escherichia coli, Enterobacter spp. and Pseudomonas aeruginosa in 1992 and 1994, β-lactamase activities were analyzed and minimum inhibitory concentrations (MICs) were determined including those of the control drugs. The results are as follows; 1. Compared to a report in 1980, the MIC distributions of CVA/TIPC against E. coli and P. aeruginosa did not show large differences. We found, however, that CVA/TIPC-resistant strains increased among Enterobacter spp. 2. Almost all of CVA/TIPC-resistant strains of Enterobacter spp. were also resistant to cephems and new quinolones, thus they were multiple drug resistant. 3. CVA/TIPC showed strong antimicrobial activities aga inst penicillinase producing E. coli.</abstract><cop>Japan</cop><pub>Japan Antibiotics Research Association</pub><pmid>8587164</pmid><doi>10.11553/antibiotics1968b.48.1899</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0368-2781 |
| ispartof | The Japanese Journal of Antibiotics, 1995/12/25, Vol.48(12), pp.1899-1905 |
| issn | 0368-2781 2186-5477 |
| language | jpn |
| recordid | cdi_proquest_miscellaneous_77798829 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Bacterial Infections - microbiology beta-Lactamase Inhibitors Clavulanic Acid Clavulanic Acids - pharmacology Drug Combinations Drug Resistance, Microbial Drug Therapy, Combination - pharmacology Enterobacter - drug effects Enterobacter - isolation & purification Escherichia coli - drug effects Escherichia coli - isolation & purification Humans Penicillins - pharmacology Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - isolation & purification Ticarcillin - pharmacology |
| title | ANTIMICROBIAL ACTIVITIES OF CLAVULANIC ACID/TICARCILLIN AGAINST CLINICAL ISOLATES |
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