ANTIMICROBIAL ACTIVITIES OF CLAVULANIC ACID/TICARCILLIN AGAINST CLINICAL ISOLATES
In order to investigate antimicrobial activities of clavulanic acid/ticarcillin (CVA/TIPC) against Escherichia coli, Enterobacter spp. and Pseudomonas aeruginosa in 1992 and 1994, β-lactamase activities were analyzed and minimum inhibitory concentrations (MICs) were determined including those of the...
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Veröffentlicht in: | Japanese journal of antibiotics 1995/12/25, Vol.48(12), pp.1899-1905 |
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Format: | Artikel |
Sprache: | jpn |
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Zusammenfassung: | In order to investigate antimicrobial activities of clavulanic acid/ticarcillin (CVA/TIPC) against Escherichia coli, Enterobacter spp. and Pseudomonas aeruginosa in 1992 and 1994, β-lactamase activities were analyzed and minimum inhibitory concentrations (MICs) were determined including those of the control drugs. The results are as follows; 1. Compared to a report in 1980, the MIC distributions of CVA/TIPC against E. coli and P. aeruginosa did not show large differences. We found, however, that CVA/TIPC-resistant strains increased among Enterobacter spp. 2. Almost all of CVA/TIPC-resistant strains of Enterobacter spp. were also resistant to cephems and new quinolones, thus they were multiple drug resistant. 3. CVA/TIPC showed strong antimicrobial activities aga inst penicillinase producing E. coli. |
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ISSN: | 0368-2781 2186-5477 |
DOI: | 10.11553/antibiotics1968b.48.1899 |