Alpha-fetoprotein and acetylcholinesterase activity in first-and early second-trimester amniotic fluid

Alpha-fetoprotein and acetylcholinesterase activity in first-and early second-trimester amniotic fluid

Normal ranges of amniotic fluid alpha‐fetoprotein (AFP) and acetylcholinesterase activity (AChE) are described for gestational weeks 11–14 using rocket gel immunoelectrophoresis for AFP quantitation and a monoclonal antibody (4F19) enzyme antigen immunoassay for AChE activity measurement. The normal...

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Veröffentlicht in:Prenatal diagnosis 1995-07, Vol.15 (7), p.621-625
Hauptverfasser: Stener Jørgensen, Finn, Sundberg, Karin, Loft, Anne Gitte Rasmussen, Arends, Jørgen, Nørgaard-Pedersen, Bent
Format: Artikel
Sprache:eng
Schlagworte:
Abdominal Muscles - abnormalities
abdominal wall defect
acetylcholinesterase
Acetylcholinesterase - analysis
Acetylcholinesterase - immunology
Acetylcholinesterase - metabolism
Adult
alpha -fetoprotein
alpha-Fetoproteins - analysis
alpha-Fetoproteins - immunology
alpha-Fetoproteins - metabolism
Amniocentesis
amniotic fluid
Amniotic Fluid - chemistry
Amniotic Fluid - metabolism
Antibodies, Monoclonal - analysis
Antibodies, Monoclonal - immunology
Biological and medical sciences
Congenital Abnormalities - diagnosis
Female
Gynecology. Andrology. Obstetrics
Humans
Immunoelectrophoresis
man
Management. Prenatal diagnosis
Medical sciences
neural tube defect
neural tube defects
Neural Tube Defects - diagnosis
normal ranges
Pregnancy
Pregnancy Trimester, First
Pregnancy Trimester, Second
Pregnancy. Fetus. Placenta
Prenatal Diagnosis
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Zusammenfassung:Normal ranges of amniotic fluid alpha‐fetoprotein (AFP) and acetylcholinesterase activity (AChE) are described for gestational weeks 11–14 using rocket gel immunoelectrophoresis for AFP quantitation and a monoclonal antibody (4F19) enzyme antigen immunoassay for AChE activity measurement. The normal ranges were established by the examination of 281 amniotic fluid samples from 281 normal pregnancies. AFP was found to increase from a median level of 14.0 MIU/1 at 11 weeks to a maximum at 13 weeks (median=18.0 MIU/l) (P
ISSN:0197-3851
1097-0223
DOI:10.1002/pd.1970150706