Application of a superparamagnetic iron oxide (Resovis®) for MR imaging of human cerebral blood volume
The authors describe the feasibility of dynamic MRI using a novel superparamagnetic iron oxide contrast agent. Resovist® was injected as a bolus at doses of 4, 8, and 16 μmol Fe/kg bodyweight in three consented patients participating in a Phase 2 clinical multicenter trial for hepatic MRI. Dynamic i...
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| Veröffentlicht in: | Magnetic resonance in medicine 1995-11, Vol.34 (5), p.694-697 |
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| container_title | Magnetic resonance in medicine |
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| creator | Reimer, Peter Schuierer, Gerhard Balzer, Thomas Peters, Peter E. |
| description | The authors describe the feasibility of dynamic MRI using a novel superparamagnetic iron oxide contrast agent. Resovist® was injected as a bolus at doses of 4, 8, and 16 μmol Fe/kg bodyweight in three consented patients participating in a Phase 2 clinical multicenter trial for hepatic MRI. Dynamic images of the brain were obtained with a conventional FLASH sequence. Results were analyzed by evaluation of dynamic images, cerebral blood volume maps, and normalized signal intensity time curves. Resovist® enabled rapid injections and a dose‐dependent strong reduction in gray and white matter signal intensity. The small injection volume and good tolerability may enable Resovist® to serve as a perfusion agent. Dedicated clinical trials are warranted to assess the potentials of Resovist® for perfusion MRI and fMRI. |
| doi_str_mv | 10.1002/mrm.1910340507 |
| format | Article |
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Resovist® was injected as a bolus at doses of 4, 8, and 16 μmol Fe/kg bodyweight in three consented patients participating in a Phase 2 clinical multicenter trial for hepatic MRI. Dynamic images of the brain were obtained with a conventional FLASH sequence. Results were analyzed by evaluation of dynamic images, cerebral blood volume maps, and normalized signal intensity time curves. Resovist® enabled rapid injections and a dose‐dependent strong reduction in gray and white matter signal intensity. The small injection volume and good tolerability may enable Resovist® to serve as a perfusion agent. Dedicated clinical trials are warranted to assess the potentials of Resovist® for perfusion MRI and fMRI.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.1910340507</identifier><identifier>PMID: 8544689</identifier><language>eng</language><publisher>Baltimore: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Blood Volume ; Cerebrovascular Circulation ; Contrast Media ; Dextrans ; Dose-Response Relationship, Drug ; Drug Combinations ; dynamic imaging ; Ferrosoferric Oxide ; Gadolinium DTPA ; Humans ; Iron ; magnetic resonance ; Magnetic Resonance Imaging ; Magnetite Nanoparticles ; Meglumine ; Organometallic Compounds ; Oxides ; Pentetic Acid - analogs & derivatives ; perfusion ; SPIO</subject><ispartof>Magnetic resonance in medicine, 1995-11, Vol.34 (5), p.694-697</ispartof><rights>Copyright © 1995 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4447-2c767ca646d9643a67ffeb1019a4a679802ed19f198e30e7a926bef31fa0eafe3</citedby><cites>FETCH-LOGICAL-c4447-2c767ca646d9643a67ffeb1019a4a679802ed19f198e30e7a926bef31fa0eafe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.1910340507$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.1910340507$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8544689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reimer, Peter</creatorcontrib><creatorcontrib>Schuierer, Gerhard</creatorcontrib><creatorcontrib>Balzer, Thomas</creatorcontrib><creatorcontrib>Peters, Peter E.</creatorcontrib><title>Application of a superparamagnetic iron oxide (Resovis®) for MR imaging of human cerebral blood volume</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>The authors describe the feasibility of dynamic MRI using a novel superparamagnetic iron oxide contrast agent. Resovist® was injected as a bolus at doses of 4, 8, and 16 μmol Fe/kg bodyweight in three consented patients participating in a Phase 2 clinical multicenter trial for hepatic MRI. Dynamic images of the brain were obtained with a conventional FLASH sequence. Results were analyzed by evaluation of dynamic images, cerebral blood volume maps, and normalized signal intensity time curves. Resovist® enabled rapid injections and a dose‐dependent strong reduction in gray and white matter signal intensity. The small injection volume and good tolerability may enable Resovist® to serve as a perfusion agent. Dedicated clinical trials are warranted to assess the potentials of Resovist® for perfusion MRI and fMRI.</description><subject>Blood Volume</subject><subject>Cerebrovascular Circulation</subject><subject>Contrast Media</subject><subject>Dextrans</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Combinations</subject><subject>dynamic imaging</subject><subject>Ferrosoferric Oxide</subject><subject>Gadolinium DTPA</subject><subject>Humans</subject><subject>Iron</subject><subject>magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetite Nanoparticles</subject><subject>Meglumine</subject><subject>Organometallic Compounds</subject><subject>Oxides</subject><subject>Pentetic Acid - analogs & derivatives</subject><subject>perfusion</subject><subject>SPIO</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1O3DAUhS1EBcPPlh2SV6gsMrVjx46XCLVAYYo0gJDYWE5yPRiSOLUn_LxUH4Ina0YzArFiZV2d832SD0J7lIwpIemPJjRjqihhnGRErqERzdI0STPF19GISE4SRhXfRFsxPhBClJJ8A23kGeciVyM0O-q62pVm7nyLvcUGx76D0JlgGjNrYe5K7MIie3EV4O9TiP7Jxbd_h9j6gCdT7Iaea2cL-L5vTItLCFAEU-Oi9r7CT77uG9hB36ypI-yu3m108-vn9fFpcnF5cnZ8dJGUnHOZpKUUsjSCi0oJzoyQ1kJBCVWGD4fKSQoVVZaqHBgBaVQqCrCMWkPAWGDb6GDp7YL_20Oc68bFEuratOD7qKWUiolcDMXxslgGH2MAq7swfCW8akr0Ylk9LKs_lh2A_ZW5Lxqo3uurKYdcLfNnV8PrFzY9mU4-uZMl6-IcXt5ZEx61kExm-vbPiZ78vqPnIr_S5-w_0kGVsw</recordid><startdate>199511</startdate><enddate>199511</enddate><creator>Reimer, Peter</creator><creator>Schuierer, Gerhard</creator><creator>Balzer, Thomas</creator><creator>Peters, Peter E.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199511</creationdate><title>Application of a superparamagnetic iron oxide (Resovis®) for MR imaging of human cerebral blood volume</title><author>Reimer, Peter ; Schuierer, Gerhard ; Balzer, Thomas ; Peters, Peter E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4447-2c767ca646d9643a67ffeb1019a4a679802ed19f198e30e7a926bef31fa0eafe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Blood Volume</topic><topic>Cerebrovascular Circulation</topic><topic>Contrast Media</topic><topic>Dextrans</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Combinations</topic><topic>dynamic imaging</topic><topic>Ferrosoferric Oxide</topic><topic>Gadolinium DTPA</topic><topic>Humans</topic><topic>Iron</topic><topic>magnetic resonance</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetite Nanoparticles</topic><topic>Meglumine</topic><topic>Organometallic Compounds</topic><topic>Oxides</topic><topic>Pentetic Acid - analogs & derivatives</topic><topic>perfusion</topic><topic>SPIO</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reimer, Peter</creatorcontrib><creatorcontrib>Schuierer, Gerhard</creatorcontrib><creatorcontrib>Balzer, Thomas</creatorcontrib><creatorcontrib>Peters, Peter E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reimer, Peter</au><au>Schuierer, Gerhard</au><au>Balzer, Thomas</au><au>Peters, Peter E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of a superparamagnetic iron oxide (Resovis®) for MR imaging of human cerebral blood volume</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1995-11</date><risdate>1995</risdate><volume>34</volume><issue>5</issue><spage>694</spage><epage>697</epage><pages>694-697</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>The authors describe the feasibility of dynamic MRI using a novel superparamagnetic iron oxide contrast agent. Resovist® was injected as a bolus at doses of 4, 8, and 16 μmol Fe/kg bodyweight in three consented patients participating in a Phase 2 clinical multicenter trial for hepatic MRI. Dynamic images of the brain were obtained with a conventional FLASH sequence. Results were analyzed by evaluation of dynamic images, cerebral blood volume maps, and normalized signal intensity time curves. Resovist® enabled rapid injections and a dose‐dependent strong reduction in gray and white matter signal intensity. The small injection volume and good tolerability may enable Resovist® to serve as a perfusion agent. 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| identifier | ISSN: 0740-3194 |
| ispartof | Magnetic resonance in medicine, 1995-11, Vol.34 (5), p.694-697 |
| issn | 0740-3194 1522-2594 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Blood Volume Cerebrovascular Circulation Contrast Media Dextrans Dose-Response Relationship, Drug Drug Combinations dynamic imaging Ferrosoferric Oxide Gadolinium DTPA Humans Iron magnetic resonance Magnetic Resonance Imaging Magnetite Nanoparticles Meglumine Organometallic Compounds Oxides Pentetic Acid - analogs & derivatives perfusion SPIO |
| title | Application of a superparamagnetic iron oxide (Resovis®) for MR imaging of human cerebral blood volume |
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