Rate of reinfection with intestinal nematodes after treatment of children with mebendazole or albendazole in a highly endemic area

The comparative efficacy of albendazole and mebendazole in the treatment of intestinal nematode infections were compared 3 weeks after treatment in a randomized trial among schoolchildren on Pemba Island, Tanzania. Egg counts were compared 3 weeks, 4 months and 6 months after treatment of 731 childr...

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Veröffentlicht in:Transactions of the Royal Society of Tropical Medicine and Hygiene 1995-09, Vol.89 (5), p.538-541
Hauptverfasser: Albonico, Marco, Smith, Peter G., Ercole, Elena, Hall, Andrew, Chwaya, Hababu M., Alawi, Kassim S., Savioli, Lorenzo
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Sprache:eng
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Zusammenfassung:The comparative efficacy of albendazole and mebendazole in the treatment of intestinal nematode infections were compared 3 weeks after treatment in a randomized trial among schoolchildren on Pemba Island, Tanzania. Egg counts were compared 3 weeks, 4 months and 6 months after treatment of 731 children seen on each occasion. Differences in the efficacies were apparent with some nematodes 21 d after treatment, but these were no longer apparent 4 months after treatment, and by 6 months intensities of infection were similar to pre-treatment levels. These findings suggest that treatment of schoolchildren every 4 months may be necessary in this highly endemic area in order to have an impact on the intensity of intestinal nematode infections sufficient to be likely to reduce morbidity.
ISSN:0035-9203
1878-3503
DOI:10.1016/0035-9203(95)90101-9